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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 9AndIssue Number: 9AndStart Page: e1003829AndDate: 2013 Revise Search
- 1From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedThe plant hormone auxin plays a critical role in regulating various aspects of plant growth and development, and the spatial accumulation of auxin within organs, which is primarily attributable to local auxin...
- 2From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedCyclic adenosine monophosphate (cAMP) has been implicated in the execution of diverse rhythmic behaviors, but how cAMP functions in neurons to generate behavioral outputs remains unclear. During the defecation motor...
- 3From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedMutations in VAPB/ALS8 are associated with amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), two motor neuron diseases that often include alterations in energy metabolism. We have shown that C....
- 4From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedCytosine DNA methylation is a stable epigenetic mark that is frequently associated with the silencing of genes and transposable elements (TEs). In Arabidopsis, the establishment of DNA methylation is through the...
- 5From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedSince 1999 a lineage of the pathogen Cryptococcus gattii has been infecting humans and of ther animals in Canada and the Pacific Northwest of the USA. It is now the largest outbreak of a life-threatening fungal...
- 6From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedEnhancers and promoters often contain multiple binding sites for the same transcription factor, suggesting that homotypic clustering of binding sites may serve a role in transcription regulation. Here we show that...
- 7From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedAlthough the genome contains all the information necessary for maintenance and perpetuation of life, it is the proteome that repairs, duplicates and expresses the genome and actually performs most cellular functions....
- 8From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedI often have one eye on the PBS NewsHour when I'm preparing dinner, but whenever the subject turns to the Supreme Court, I snap to full attention. I love the NewsHour's Marcia Coyle who, like her equally engaging...
- 9From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedAll genomes require a system for avoidance or handling of collisions between the machineries of DNA replication and transcription. We have investigated the roles in this process of the mTERF (mitochondrial transcription...
- 10From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedGenome-wide association studies and follow-up meta-analyses in Crohn's disease (CD) and ulcerative colitis (UC) have recently identified 163 disease-associated loci that meet genome-wide significance for these two...
- 11From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedWhole-exome or gene targeted resequencing in hundreds to thousands of individuals has shown that the majority of genetic variants are at low frequency in human populations. Rare variants are enriched for functional...
- 12From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedThe worldwide production of maize (Zea mays L.) is frequently impacted by water scarcity and as a result, increased drought tolerance is a priority target in maize breeding programs. While DREB transcription factors...
- 13From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedTranscriptional elongation requires the concerted action of several factors that allow RNA polymerase II to advance through chromatin in a highly processive manner. In order to identify novel elongation factors, we...
- 14From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedThe Yorkie/Yap transcriptional coactivator is a well-known regulator of cellular proliferation in both invertebrates and mammals. As a coactivator, Yorkie (Yki) lacks a DNA binding domain and must partner with...
- 15From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedCytosine methylation of DNA is an important epigenetic gene silencing mechanism in plants, fungi, and animals. In the filamentous fungus Neurospora crassa, nearly all known DNA methylations occur in transposon relics...
- 16From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedSingle base substitutions constitute the most frequent type of human gene mutation and are a leading cause of cancer and inherited disease. These alterations occur non-randomly in DNA, being strongly influenced by the...
- 17From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedDiscriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci called CRISPRs (clustered regularly interspaced short palindromic...
- 18From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedWhole genome sequencing is a powerful tool in the discovery of single nucleotide polymorphisms (SNPs) and small insertions/deletions (indels) among mutant strains, which simplifies forward genetics approaches. However,...
- 19From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedThe Unfolded Protein Response (UPR) maintains homeostasis in the endoplasmic reticulum (ER) and defends against ER stress, an underlying factor in various human diseases. During the UPR, numerous genes are activated...
- 20From: PLoS Genetics. (Vol. 9, Issue 9) Peer-ReviewedGenetic information should be accurately transmitted from cell to cell; conversely, the adaptation in evolution and disease is fueled by mutations. In the case of cancer development, multiple genetic changes happen in...