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- 1From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedMicrobial infection during various stages of human development produces widely different clinical outcomes, yet the links between age-related changes in the immune compartment and functional immunity remain unclear. The...
- 2From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedEvolution of pathogen virulence is affected by the route of infection. Also, alternate infection routes trigger different physiological responses on hosts, impinging on host adaptation and on its interaction with...
- 3From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedPrions are infectious agents causing fatal neurodegenerative diseases of humans and animals. In humans, these have sporadic, acquired and inherited aetiologies. The inherited prion diseases are caused by one of over 30...
- 4From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedThe innate immune system of Anopheles gambiae mosquitoes limits Plasmodium infection through multiple molecular mechanisms. For example, midgut invasion by the parasite triggers an epithelial nitration response that...
- 5From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedAutophagy, an ancient and highly conserved intracellular degradation process, is viewed as a critical component of innate immunity because of its ability to deliver cytosolic bacteria to the lysosome. However, the...
- 6From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedOverview To discriminate self from non-self, the innate immune system evolved a large repertoire of germline-encoded receptors that detect molecular patterns associated with infections [1]. As originally proposed by...
- 7From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedLytic gammaherpesvirus (GHV) replication facilitates the establishment of lifelong latent infection, which places the infected host at risk for numerous cancers. As obligate intracellular parasites, GHVs must control...
- 8From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedThe maternally inherited intracellular bacteria Wolbachia can manipulate host reproduction in various ways that foster frequency increases within and among host populations. Manipulations involving cytoplasmic...
- 9From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedMany pathogenic fungi are dimorphic and switch between yeast and filamentous states. This switch alters host-microbe interactions and is critical for pathogenicity. However, in zygomycetes, whether dimorphism...
- 10From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedHuman rhinovirus (RV) infections are the principle cause of common colds and precipitate asthma and COPD exacerbations. There is currently no RV vaccine, largely due to the existence of -150 strains. We aimed to define...
- 11From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedA desirable but as yet unachieved property of a human immunodeficiency virus type 1 (HIV-1) vaccine candidate is the ability to induce broadly neutralizing antibodies (bNAbs). One approach to the problem is to create...
- 12From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedThe causative agent of Legionnaires' disease, Legionella pneumophila, uses the Icm/Dot type IV secretion system (T4SS) to form in phagocytes a distinct "Leg/onella-containing vacuole" (LCV), which intercepts endosomal...
- 13From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedEpstein-Barr virus (EBV) causes a persistent infection in human B cells by establishing specific transcription programs to control B cell activation and differentiation. Transcriptional reprogramming of EBV infected B...
- 14From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedThe complement C3-like protein TEP1 of the mosquito Anopheles gambiae is required for defense against malaria parasites and bacteria. Two forms of TEP1 are present in the mosquito hemolymph, the full-length TEP1-F and...
- 15From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedProgeny particles of non-enveloped lytic parvoviruses were previously shown to be actively transported to the cell periphery through vesicles in a gelsolin-dependent manner. This process involves rearrangement and...
- 16From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedDrug resistant pathogens are one of the key public health challenges of the 21st century. There is a widespread belief that resistance is best managed by using drugs to rapidly eliminate target pathogens from patients...
- 17From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedWhile the concept of programmed cell death (PCD) or its morphological equivalent, apoptosis, was recognized in pockets of research prior to the 1970s, it was not until 1972 that Kerr, Wyllie, and Currie [1] first...
- 18From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedThe treatment of schistosomiasis, a disease caused by blood flukes parasites of the Schistosoma genus, depends on the intensive use of a single drug, praziquantel, which increases the likelihood of the development of...
- 19From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedAlthough the protective functions by T helper 17 (Th17) cytokines against extracellular bacterial and fungal infection have been well documented, their importance against intracellular bacterial infection remains...
- 20From: PLoS Pathogens. (Vol. 9, Issue 9) Peer-ReviewedHendra virus (HeV) is a recently emerged severe human pathogen that belongs to the Henipavirus genus within the Paramyxoviridae family. The HeV genome is encapsidated by the nucleoprotein (N) within a helical...