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- 1From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedFamilial pancreatic cancer (FPC) describes families with at least two first-degree relatives with confirmed exocrine pancreatic cancer that do not fulfil the criteria of other inherited tumour syndromes with increased...
- 2From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedA recent study investigated whether pancreatic cysts might be a risk factor for pancreatic cancer. The incidence and characteristics of pancreatic cysts found by MRI in patients with and without pancreatic cancer were...
- 3From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedEffective colonoscopy relies on adequate bowel cleansing. Now, two new papers published in Endoscopy show that a novel colon cleansing system is a safe and effective means to improve cleaning of the colon prior to...
- 4From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedThe worldwide propensity to allocate extended criteria donor livers to patients with a low MELD score has been called into question by work published in Transplantation Proceedings. "Our results suggest that contrary to...
- 5From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedPancreatic ductal adenocarcinoma (PDAC) is one of the five most lethal malignancies worldwide and survival has not improved substantially in the past 30 years. Desmoplasia (abundant fibrotic stroma) is a typical feature...
- 6From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedPatients with metastatic colorectal cancer (CRC) who show dramatic and rapid responses to targeted agents inevitably develop resistance. Now, two articles published in Nature bring us closer to defining the molecular...
- 7From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedHepatitis E virus (HEV) infection is the most common cause of hepatitis worldwide. In the developing world, HEV infection is also a common cause of decompensation in patients with chronic liver disease and has a very...
- 8From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedPancreatic cancer cells and precursor lesions in mice can be visualized with a novel imaging method that uses a labelled toxin fragment from Clostridium perfringens, according to new research. "Given the appalling...
- 9From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedLaparoscopic greater curvature plication (LGCP) is a new metabolic/bariatric surgery technique that reduces the gastric volume by placing at least two rows of nonabsorbable sutures on the greater gastric curvature....
- 10From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedTwo recent papers have found that the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), which is upregulated in many human pancreatic cancers, effectively 'masks' the tumour from the immune system. In...
- 11From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedA meta-analysis was performed to assess the accuracy of contrast-enhanced endoscopic ultrasonography (EUS) for distinguishing pancreatic adenocarcinoma from other pancreatic masses. 12 studies were included in the...
- 12From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedBurza and colleagues performed a matched, prospective, controlled, interventional trial to investigate the association of the PNPLA3 I148M genetic variant with hepatocellular carcinoma in obese individuals. The study...
- 13From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedVarious methods screen for alcohol consumption in patients with alcoholic liver disease. However, each test has its own limitations. The feasibility of the methanol test for identifying recent alcohol consumption in...
- 14From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedLate diagnosis of pancreatic ductal adenocarcinoma (pancreatic cancer) and the limited response to current treatments results in an exceptionally poor prognosis. Advances in our understanding of the molecular events...
- 15From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedPancreatic surgery is challenging for both surgeon and patient. With the advent of minimally invasive surgical techniques, patient morbidity could be reduced. However, these techniques must conform to established...
- 16From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedNew findings indicate that platelets could have a key role in the pathogenesis of HBV-associated hepatocellular carcinoma (HCC), potentially opening the door for antiplatelet therapy in patients with chronic HBV...
- 17From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-Reviewed"The sensitivity of current factors used to predict malignant intraductal papillary mucinous neoplasm (IPMN) is not high," says Masao Tanaka (Kyushu University, Japan). "Thus, more sensitive factors predictive of...
- 18From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedPancreatic cancer is a highly lethal malignancy that presents multiple technical challenges for genomic studies. Next-generation sequencing and its applications have proven successful in the study of other tumour types,...
- 19From: Nature Reviews Gastroenterology & Hepatology. (Vol. 9, Issue 8) Peer-ReviewedAcute pancreatitis is the most common and feared complication following endoscopic retrograde cholangiopancreatography (ERCP). Pharmacological prevention of post-ERCP pancreatitis has been disappointing, especially in...