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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 9AndIssue Number: 8AndStart Page: e1003715AndDate: 2013 Revise Search
- 1From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedSalt stress is an important environmental factor that significantly limits crop productivity worldwide. Studies on responses of plants to salt stress in recent years have identified novel signaling pathways and have...
- 2From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedCalpains are [Ca.sup.2+]-dependent modulator Cys proteases that have a variety of functions in almost all eukaryotes. There are more than 10 well-conserved mammalian calpains, among which eutherian calpain-6 (CAPN6) is...
- 3From: PLoS Genetics. (Vol. 9, Issue 8) Peer-Reviewed8-oxoG is one of the most common and mutagenic DNA base lesions caused by oxidative damage. However, it has not been possible to study the replication of a known 8-oxoG base in vivo in order to determine the accuracy of...
- 4From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedDyskeratosis congenita (DC) is a heterogeneous inherited bone marrow failure and cancer predisposition syndrome in which germline mutations in telomere biology genes account for approximately one-half of known families....
- 5From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedThe skin secretion of many amphibians contains an arsenal of bioactive molecules, including hormone-like peptides (HLPs) acting as defense toxins against predators, and antimicrobial peptides (AMPs) providing protection...
- 6From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedCryptococcus neoformans is a human fungal pathogen with a defined sexual cycle. Nutrient-limiting conditions and pheromones induce a dimorphic transition from unicellular yeast to multicellular hyphae and the production...
- 7From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedThe Cleavage Factor 1A (CF1A) complex, which is required for the termination of transcription in budding yeast, occupies the 3' end of transcriptionally active genes. We recently demonstrated that CF1A subunits also...
- 8From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedATR activation is dependent on temporal and spatial interactions with partner proteins. In the budding yeast model, three Proteins--[Dpb11.sup.TopBP1], [Ddc1.sup.Rad9] and Dna2--all interact with and activate...
- 9From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedThe development of morphological traits occurs through the collective action of networks of genes connected at the level of gene expression. As any node in a network may be a target of evolutionary change, the recurrent...
- 10From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedThe role of Wnt signaling in embryonic development and stem cell maintenance is well established and aberrations leading to the constitutive up-regulation of this pathway are frequent in several types of human cancers....
- 11From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedEven a single mutation can cause a marked change in a protein's properties. When the mutant protein functions within a network, complex phenotypes may emerge that are not intrinsic properties of the protein itself....
- 12From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedFabry disease (FD) is an X-linked hereditary defect of glycosphingolipid storage caused by mutations in the gene encoding the lysosomal hydrolase [alpha]-galactosidase A (GLA, [alpha]-gal A). To date, over 400 mutations...
- 13From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedThe late 1980s witnessed the debut of DNA on the stages of the world's judiciaries. In the United Kingdom, DNA "minisatellites" (discovered by Sir Alec Jeffreys and chronicled previously in this series of PLOS Genetics...
- 14From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedMeiotic recombination, an essential aspect of sexual reproduction, is initiated by programmed DNA double-strand breaks (DSBs). DSBs are catalyzed by the widely-conserved Spo11 enzyme; however, the activity of Spo11 is...
- 15From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedMultiple rare variants either within or across genes have been hypothesised to collectively influence complex human traits. The increasing availability of high throughput sequencing technologies offers the opportunity...
- 16From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedMost yeast ribosomal protein genes are duplicated and their characterization has led to hypotheses regarding the existence of specialized ribosomes with different subunit composition or specifically-tailored functions....
- 17From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedNon-homologous end-joining (NHEJ) and homologous recombination (HR) represent the two main pathways for repairing DNA double-strand breaks (DSBs). During the G2 phase of the mammalian cell cycle, both processes can...
- 18From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedCilia are architecturally complex organelles that protrude from the cell membrane and have signalling, sensory and motility functions that are central to normal tissue development and homeostasis. There are two broad...
- 19From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedCentral obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted...
- 20From: PLoS Genetics. (Vol. 9, Issue 8) Peer-ReviewedEnvironmental strain Burkholderia sp. DNT mineralizes the xenobiotic compound 2,4-dinitrotoluene (DNT) owing to the catabolic dnt genes borne by plasmid DNT, but the process fails to promote significant growth. To...