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Academic Journals
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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 9AndIssue Number: 7AndStart Page: e1003655AndDate: 2013 Revise Search
- 1From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedThe MUS-81, SLX-1, and XPF-1 structure-selective endonucleases have been implicated in meiotic crossover (CO) formation in a variety of organisms, but their contributions to C. elegans CO formation have been unclear. In...
- 2From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedFragile X syndrome (FXS), the leading cause of inherited intellectual disability, is caused by epigenetic silencing of the FMR1 gene, through expansion and methylation of a CGG triplet repeat (methylated full mutation)....
- 3From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedThe molecular chaperone Hsp90 is essential in eukaryotes, in which it facilitates the folding of developmental regulators and signal transduction proteins known as Hsp90 clients. In contrast, Hsp90 is not essential in...
- 4From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedDietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4[alpha]-related nuclear hormone receptor...
- 5From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedThe phosphorylation state of the C-terminal domain (CTD) of the RNA polymerase II plays crucial roles in transcription and mRNA processing. Previous studies showed that the plant CTD phosphatase-like 1 (CPL1)...
- 6From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedDespite important advances from Genome Wide Association Studies (GWAS), for most complex human traits and diseases, a sizable proportion of genetic variance remains unexplained and prediction accuracy (PA) is usually...
- 7From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedMutations of SLC26A4 are a common cause of human hearing loss associated with enlargement of the vestibular aqueduct. SLC26A4 encodes pendrin, an anion exchanger expressed in a variety of epithelial cells in the...
- 8From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedThe male-specific region of the human Y chromosome (MSY) includes eight large inverted repeats (palindromes) in which arm-to-arm similarity exceeds 99.9%, due to gene conversion activity. Here, we studied one of these...
- 9From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedHypomethylating agents reactivate tumor suppressor genes that are epigenetically silenced in cancer. Inevitably these genes are resilenced, leading to drug resistance. Using the MLH1 tumor suppressor gene as a model, we...
- 10From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedNTRK3 is a member of the neurotrophin receptor family and regulates cell survival. It appears to be a dependence receptor, and thus has the potential to act as an oncogene or as a tumor suppressor gene. NTRK3 is a...
- 11From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedNeural tube defects (NTDs) is a general term for central nervous system malformations secondary to a failure of closure or development of the neural tube. The resulting pathologies may involve the brain, spinal cord...
- 12From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedSignaling levels within sensory neurons must be tightly regulated to allow cells to integrate information from multiple signaling inputs and to respond to new stimuli. Herein we report a new role for the cGMP-dependent...
- 13From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedThe metabolic capabilities and regulatory networks of bacteria have been optimized by evolution in response to selective pressures present in each species' native ecological niche. In a new environment, however, the...
- 14From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedChemical defense is one of the most important traits, which endow insects the ability to conquer a most diverse set of ecological environments. Chemical secretions are used for defense against anything from vertebrate...
- 15From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedChromatin insulators block the action of transcriptional enhancers when interposed between an enhancer and a promoter. In this study, we examined the role of chromatin loops formed by two unrelated insulators, gypsy and...
- 16From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedGrowth rate and nutrient availability are the primary determinants of size in single-celled organisms: rapidly growing Escherichia coli cells are more than twice as large as their slow growing counterparts. Here we...
- 17From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedDeedu (DU) Mongolians, who migrated from the Mongolian steppes to the Qinghai-Tibetan Plateau approximately 500 years ago, are challenged by environmental conditions similar to native Tibetan highlanders. Identification...
- 18From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedAlternative splicing of precursor messenger RNA (pre-mRNA) is common in mammalian cells and enables the production of multiple gene products from a single gene, thus increasing transcriptome and proteome diversity....
- 19From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedThe core planar polarity proteins are required to specify the orientation of structures that are polarised in the plane of the epithelium. In the Drosophila melanogaster wing, the core proteins localise asymmetrically...
- 20From: PLoS Genetics. (Vol. 9, Issue 7) Peer-ReviewedLeprosy is a chronic infectious disease caused by Mycobacterium Leprae, where the host genetic background plays an important role toward the disease pathogenesis. Various studies have identified a number of human genes...