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- 1From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedSimultaneous multiview light-sheet microscopy using two illumination and two detection arms with one- or two-photon illumination is coupled to a fast data acquisition framework and analysis pipeline for quantitative...
- 2From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedMonomeric (m)Eos2 is an engineered photoactivatable fluorescent protein widely used for super-resolution microscopy. We show that mEos2 forms oligomers at high concentrations and forms aggregates when labeling membrane...
- 3From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedBioImageXD puts open-source computer science tools for three-dimensional visualization and analysis into the hands of all researchers, through a user-friendly graphical interface tuned to the needs of biologists....
- 4From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedFew technologies are more widespread in modern biological laboratories than imaging. Recent advances in optical technologies and instrumentation are providing hitherto unimagined capabilities. Almost all these advances...
- 5From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedEpigenetic marks do not act alone. DNA and histone modifications can be grouped into epigenetic 'states' that affect gene expression and cell identity in both normal development and disease. The hunt for these states...
- 6From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedImaging in biology has recently seen a revolution in scope and scale, necessitating developments in image informatics on several fronts. New, sophisticated bioimaging techniques yield large, heterogeneous,...
- 7From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedA genetically encoded tag for protein identification in transmission electron microscopy would be useful for studying cellular ultrastructure. Some such approaches have been previously reported, but tags that are...
- 8From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedInvestigators intent on cracking one code may overlook another. So back in the days when the DNA sequence alone was believed to hold all cellular secrets, histones, the protein cores that spool DNA, were dismissed as...
- 9From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedTo the Editor: Advances in high-content fluorescence microscopy have driven the development of analytical approaches for extracting meaningful information from rich and complex biological image data. Algorithm...
- 10From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedWe present a toolbox for high-throughput screening of image-based Caenorhabditis elegans phenotypes. The image analysis algorithms measure morphological phenotypes in individual worms and are effective for a variety of...
- 11From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedTo the Editor: Choosing among algorithms for analyzing biological images can be a daunting task, especially for nonexperts. Software toolboxes such as CellProfiler (1,2) and ImageJ (3) make it easy to try out algorithms...
- 12From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedFiji is a distribution of the popular open-source software ImageJ focused on biological-image analysis. Fiji uses modern software engineering practices to combine powerful software libraries with a broad range of...
- 13From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedAnalysis of cellular phenotypes in large imaging data sets conventionally involves supervised statistical methods, which require user-annotated training data. This paper introduces an unsupervised learning method, based...
- 14From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedBy the end of 2001, the human genome and those of the major model organisms--Caenorhabditis elegans, Drosophila melanogaster and Mus musculus--had been sequenced (1-5). With the genetic code in hand, the imperative...
- 15From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedWe present a multiview selective-plane illumination microscope (MuVi-SPIM), comprising two detection and illumination objective lenses, that allows rapid in toto fluorescence imaging of biological specimens with...
- 16From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedTo the Editor: Recent advances in fluorescence microscopy have enabled unprecedented progress in many areas of biology. With the technology to perform high-content image-based screens now accessible to many labs, the...
- 17From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedThe last 50 years have seen tremendous technological advances, few greater than in the area of scientific computing. One of the fields in which scientific computing has made particular inroads has been the area of...
- 18From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedThere is no question that the localization of mRNAs in the cell matters. In neurons, for example, local protein synthesis at the dendrites is required for certain forms of learning and memory. However, documentation of...
- 19From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedTo the Editor: Fluorescence microscopy is growing dramatically both in terms of technical capabilities and the volume of images generated. Online repositories have been created to provide public access to images and...
- 20From: Nature Methods. (Vol. 9, Issue 7) Peer-ReviewedImitating nature's assembly lines would help researchers make effective biodevices, but too much is still unknown about the process by which proteins and nucleic acids come together to form active complexes. Heyman et...