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- 1From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedThe genetic basis of early plant development has proved challenging to dissect: the cells of interest are surrounded by tissue and therefore hard to get at, and functional redundancy makes it hard to link genotypes to...
- 2From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedUnderstanding the ancestral relationship between genes is essential for gene annotation, prediction of function and comparative genomics. A new study questions the accuracy of current approaches for inferring gene...
- 3From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedAbstract | It has been known for decades that some clinically important viruses encode abundant amounts of non-coding RNAs (ncRNAs) during infection. Until recently, the number of viral ncRNAs identified was few and...
- 4From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedWolf, J. B., Cheverud, J. M., Rosernan, C. & Hager, R. PLoS Genet. 4, e1000091 (2008) Although we understand several well-documented cases of imprinting at individual loci, we know little about the contribution of...
- 5From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedPigmentation traits, including fair skin, red or blonde hair, blue or green eyes, and freckles, are known risk factors for skin cancer, owing in part to the ability of darker pigmentation to protect skin from the sun's...
- 6From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedAbstract | Multiple sclerosis (MS) is an autoimmune demyelinating disease and a common cause of neurological disability in young adults. The modest heritability of MS reflects complex genetic effects and multifaceted...
- 7From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedMeng, X. et al. Nature Methods 25 May 2008 (doi:10.1038/nbt 1398) Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Doyon, Y et al Nature Methods 25 May 2008 (doi:10.1038/nbt 1409)...
- 8From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedYang, S-H, Cheng, P-H., Banta, H. et al. Nature 18 May 2008 (doi:10.1038/nature06975) Although mouse and fly models of Huntington disease (HD) have helped to understand the molecular basis of this triplet-repeat...
- 9From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedAbstract | Retinoic acid (RA) has complex and pleiotropic functions during vertebrate development. Recent work in several species has increased our understanding of the roles of RA as a signalling molecule. These...
- 10From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedWe have plenty of lists of mutations that are associated with cancers, but little data on how these mutations interact with each other. A new, large-scale mutagenesis screen in different mouse backgrounds identifies...
- 11From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedAbstract | The remarkable gene knockdown technique of RNAi has opened exciting new avenues for genetic screens in model organisms and human cells. Here we describe the current state of the art for RNAi screening, and...
- 12From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedThe creation of a transgenic mouse expressing a gene from the extinct Tasmanian tiger was always going to be a headline grabber. Andrew Pask and colleagues at the University of Melbourne have isolated an enhancer...
- 13From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedThere is a considerable amount of noise within our cells, owing to the variable expression of many genes. A new theoretical model that incorporates noise has been applied to understand how multipotent cells make fate...
- 14From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedA recent study provides the first genome-wide investigation of the relationship between common human genetic variation and levels of disease-related proteins. The findings have implications for understanding the...
- 15From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedFan L. & Fuss, J. O. et al. Cell 133. 789-800 (2008) Structure of the DNA repair helicase XPD. Liu, H. & Rudolf, J. et al. Cell 133 801-812 (2008) The structural and enzymatic study of the archaeal homologue of the...
- 16From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedNetworks can be constructed from various types of genome-wide data to predict the properties of complex genetic systems. A new study shows that the power of networks to predict biological properties of the genes involved...
- 17From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedRay, A., van der Goes van Naters, W. & Carlson. J. R. PLoS Biol. 6, e 125 (2008) Comparative genomics and experimental manipulation were used to detect the control regions that target the expression of specific...
- 18From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedAs complex traits go, psychiatric conditions are about as complicated as you get, characterized as they are by many distinct biological mechanisms, genetic, allelic and phenotypic heterogeneity, and environmental...
- 19From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedThe depth of cells--the number of cell divisions since the zygote--can be assessed by eye in Caenorhabditis elegans, but has been difficult to estimate accurately in humans and in mice. A new study has developed a...
- 20From: Nature Reviews Genetics. (Vol. 9, Issue 7) Peer-ReviewedNembaware, V et al BMC Genomics 9, 265 (2008) Links between allele-specific splicing differences and disease susceptibility mean that being able to predict the effect of a polymorphism on splicing is an important goat....