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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 9AndIssue Number: 6AndStart Page: e1003096AndDate: 2013 Revise Search
- 1From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedThe pilus 2a backbone protein (BP-2a) is one of the most structurally and functionally characterized components of a potential vaccine formulation against Group B Streptococcus. It is characterized by six main...
- 2From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedThe protein kinases are a large family of enzymes that play fundamental roles in propagating signals within the cell. Because of the high degree of binding site similarity shared among protein kinases, designing drug...
- 3From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedDespite the clinical ubiquity of anesthesia, the molecular basis of anesthetic action is poorly understood. Amongst the many molecular targets proposed to contribute to anesthetic effects, the voltage gated sodium...
- 4From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedMolecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a...
- 5From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedIdentification of responsive genes to an extra-cellular cue enables characterization of pathophysiologically crucial biological processes. Deep sequencing technologies provide a powerful means to identify responsive...
- 6From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedIntroduction The International Society for Computational Biology (ISCB; http://www.iscb.org) honors a senior scientist each year for his or her outstanding achievements. The ISCB Accomplishment by a Senior Scientist...
- 7From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedWe provide an integrated dynamic view on a eukaryotic osmolyte system, linking signaling with regulation of gene expression, metabolic control and growth. Adaptation to osmotic changes enables cells to adjust cellular...
- 8From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedAlthough many methods are available to test sequence variants for association with complex diseases and traits, methods that specifically seek to identify causal variants are less developed. Here we develop and evaluate...
- 9From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedMany cellular stress-responsive signaling systems exhibit highly dynamic behavior with oscillatory features mediated by delayed negative feedback loops. What remains unclear is whether oscillatory behavior is the basis...
- 10From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedThe learning mechanism in the hippocampus has almost universally been assumed to be Hebbian in nature, where individual neurons in an engram join together with synaptic weight increases to support facilitated recall of...
- 11From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedThromboembolic disease is a leading cause of morbidity and mortality worldwide. In the last several years there have been a number of studies attempting to identify mechanisms that stop thrombus growth. This paper...
- 12From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedReversible phosphorylation is one of the major mechanisms of signal transduction, and signaling networks are critical regulators of cell growth and development. However, few of these networks have been delineated...
- 13From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedProteolytic processing of Gag and Gag-Pol polyproteins by the viral protease (PR) is crucial for the production of infectious HIV-1, and inhibitors of the viral PR are an integral part of current antiretroviral therapy....
- 14From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedA fundamental issue in locomotion is to understand how muscle forcing produces apparently complex deformation kinematics leading to movement of animals like undulatory swimmers. The question of whether complicated...
- 15From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedEpithelial cells in the colon are arranged in cylindrical structures called crypts in which cellular proliferation and migration are tightly regulated. We hypothesized that the proliferation patterns of cells may...
- 16From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedSince 2010, the European Molecular Biology Laboratory's (EMBL) Heidelberg laboratory and the European Bioinformatics Institute (EMBL-EBI) have jointly run bioinformatics training courses developed specifically for...
- 17From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedThe characteristics of the host contact network over which a pathogen is transmitted affect both epidemic spread and the projected effectiveness of control strategies. Given the importance of understanding these contact...
- 18From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedDesigned peptides that bind to major histocompatibility protein I (MHC-I) allomorphs bear the promise of representing epitopes that stimulate a desired immune response. A rigorous bioinformatical exploration of sequence...
- 19From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedSmall-World Networks (SWNs) represent a fundamental model for the comprehension of many complex man-made and biological networks. In the central nervous system, SWN models have been shown to fit well both anatomical and...
- 20From: PLoS Computational Biology. (Vol. 9, Issue 6) Peer-ReviewedThe pyrabactin resistance 1 (PYR1)/PYR1-like (PYL)/regulatory component of abscisic acid (ABA) response (RCAR) proteins comprise a well characterized family of ABA receptors. Recent investigations have revealed two...