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- 1From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedMeiosis is a modified cell division in which a single S-phase is followed by two rounds of chromosome segregation resulting in the production of haploid gametes. The meiotic mode of chromosome segregation requires...
- 2From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedNucleosomes in all eukaryotes examined to date adopt a characteristic architecture within genes and play fundamental roles in regulating transcription, yet the identity and precise roles of many of the trans-acting...
- 3From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedClassical genetic studies aim to understand how genes determine biological processes, physical characteristics, behaviour, and disease by identifying heritable variations in DNA sequence that associate with specific...
- 4From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedThere is increasing evidence that heritable variation in gene expression underlies genetic variation in susceptibility to disease. Therefore, a comprehensive understanding of the similarity between relatives for...
- 5From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedMapping expression Quantitative Trait Loci (eQTLs) represents a powerful and widely adopted approach to identifying putative regulatory variants and linking them to specific genes. Up to now eQTL studies have been...
- 6From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedImportant knowledge about the determinants of complex human phenotypes can be obtained from the estimation of heritability, the fraction of phenotypic variation in a population that is determined by genetic factors....
- 7From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedPairing of homologous chromosomes during early meiosis is essential to prevent the formation of aneuploid gametes. Chromosome pairing includes a step of homology search followed by the stabilization of homolog...
- 8From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedAnimals harbor specialized neuronal systems that are used for sensing and coordinating responses to changes in oxygen ([O.sub.2]) and carbon dioxide (C[O.sub.2]). In Caenorhabditis elegans, the [O.sub.2]/C[O.sub.2]...
- 9From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedCell cycle progression, including genome duplication, is orchestrated by cyclin-dependent kinases (CDKs). CDK activation depends on phosphorylation of their T-loop by a CDK-activating kinase (CAK). In animals, the only...
- 10From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedIn the pre-genome era, most of what we knew about molecular evolution could be traced to our knowledge of the genetic code, and the impact of DNA sequence variation on protein structure and, by inference, protein...
- 11From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedHumans and dogs are both affected by the allergic skin disease atopic dermatitis (AD), caused by an interaction between genetic and environmental factors. The German shepherd dog (GSD) is a high-risk breed for canine AD...
- 12From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedPIN-FORMED (PIN) proteins localize asymmetrically at the plasma membrane and mediate intercellular polar transport of the plant hormone auxin that is crucial for a multitude of developmental processes in plants. PIN...
- 13From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedCombining data from genome-wide association studies (GWAS) conducted at different locations, using genotype imputation and fixed-effects meta-analysis, has been a powerful approach for dissecting complex disease...
- 14From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedATM plays a critical role in cellular responses to DNA double-strand breaks (DSBs). We describe a new ATM-mediated DSBinduced DNA damage response pathway involving microRNA (miRNA): irradiation (IR)-induced DSBs...
- 15From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedThe Rhox cluster on the mouse X chromosome contains reproduction-related homeobox genes expressed in a sexually dimorphic manner. We report that two members of the Rhox cluster, Rhox6 and 9, are regulated by...
- 16From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedThe study of chromosomal organization and segregation in a handful of bacteria has revealed surprising variety in the mechanisms mediating such fundamental processes. In this study, we further emphasized this diversity...
- 17From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedCanonical Wnt signaling plays a rate-limiting role in regulating self-renewal and differentiation in mouse embryonic stem cells (ESCs). We have previously shown that mutation in the Apc (adenomatous polyposis coli)...
- 18From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedRNA-mediated transmission of phenotypes is an important way to explain non-Mendelian heredity. We have previously shown that small non-coding RNAs can induce hereditary epigenetic variations in mice and act as the...
- 19From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedSkin pigment patterns of vertebrates are a classic system for understanding fundamental mechanisms of morphogenesis, differentiation, and pattern formation, and recent studies of zebrafish have started to elucidate the...
- 20From: PLoS Genetics. (Vol. 9, Issue 5) Peer-ReviewedModern functional genomics uncovered numerous functional elements in metazoan genomes. Nevertheless, only a small fraction of the typical non-exonic genome contains elements that code for function directly. On the other...