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- 1From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedBorel, C. et oL Am. J. Hum. Genet. 82, 971-981 (2008). The authors used tiling arrays for the ENCODE region of the genome (about 1% of the total) to look at expression in human cell lines of RNAs that are smaller than...
- 2From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedAbstract | Autism is a heterogeneous syndrome defined by impairments in three core domains: social interaction, language and range of interests. Recent work has led to the identification of several autism susceptibility...
- 3From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedSankararaman, S. et al. Genome Res. 18, 668-675 (2008 Effect of genetic divergence in identifying ancestral origin using HAPAA. Sundquist, A. et al. Genome Res. 18, 676-682 (2008) To address the potential...
- 4From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedLow copy number (LCN) DNA forensic profiling has lead to successful criminal prosecutions, including in the Peter Falconio case in Australia and the murder of the Swedish foreign minister, Anna Lindh. However, the...
- 5From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedPolyglutamine diseases are dominant neurodegenerative disorders caused by expansion of unstable CAG repeats in coding regions of a number of genes. Although this polyglutamine expansion is responsible for the toxic...
- 6From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedOver the last few years, one term has dominated genetic thinking in the arena of complex human disease: genome-wide association (GWA). It has been said, many times, that the ability to scan the genome in an unbiased way...
- 7From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedMaynard, N. D. etol Nature Methods 5, 307-309 (2008) Imprinting,dosage compensation and several other mechanisms can lead to the two alleles of a locus being differentially expressed. The authors developed a method...
- 8From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedIdentifying the heritable component of psychiatric conditions is one of the biggest challenges of human genetic research. A new study published in Science reveals that rare structural variants in neurodevelopmental genes...
- 9From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedIn their Perspective (A unified classification system for eukaryotic transposable elements. Nature Rev. Genet. 8, 973-982 (2007)) (1), Wicker et al. attempt to introduce the 'first universal classification scheme. Here,...
- 10From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedTischler, J. et al Nature Genet. 40, 390-391 (2008 Given the importance of nonadditive genetic interactions in genetic disorders, the authors used RNAi to determine whether synthetic lethal interactions detected in...
- 11From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedAbstract | The body axis of vertebrates is composed of a serial repetition of similar anatomical modules that are called segments or metameres. This particular mode of organization is especially conspicuous at the level...
- 12From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedAbstract | Recent advances in high-throughput genomic technologies are showing concrete results in the form of an increasing number of genome-wide association studies and in the publication of comprehensive individual...
- 13From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedTam, O. H. et oL Nature 13 Al Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Watanabe, T et oL Nature 13 Apr 2008 (doi:10.1038/natu Two papers report roles for endogenous...
- 14From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedThe trouble with many forward gene-hunting strategies--be it association studies in humans or mutagenesis screens in model organisms--is that there is no straightforward way of finding out how any of the candidate genes...
- 15From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedOur view of gene regulation is increasingly three-dimensional--studies in the past few years suggest that repositioning of loci within the nucleus is important for coordinated expression. A recent paper reveals that an...
- 16From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedAbstract | Following the acquisition of chloroplasts and mitochondria by eukaryotic cells during endosymbiotic evolution, most of the genes in these organelles were either lost or transferred to the nucleus. Encoding...
- 17From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedBasanta, D. et al. PLoS Comp. Biol. 28 Mar 2008 (doi:10.1371/journal. pcbi.1000030) The authors generated developing and evolvable multicellular organisms in silico to study the emergence of morphogenetic...
- 18From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedAbstract | The past year has witnessed substantial advances in understanding the genetic basis of many common phenotypes of biomedical importance. These advances have been the result of systematic, well-powered,...
- 19From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedMammalian reproduction relies on two important evolutionary inventions--lactation and placentation. Two recent papers shed light on how and when these important characteristics evolved. Most vertebrates are egg laying,...
- 20From: Nature Reviews Genetics. (Vol. 9, Issue 5) Peer-ReviewedEskin, E. Genome Res. 18, 653-660 (2008) This new method for increasing the power of genome-wide association studies incorporates prior knowledge about genetic markers into the design. In the new framework, called...