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Academic Journals
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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 9AndIssue Number: 4AndStart Page: e1003413AndDate: 2013 Revise Search
- 1From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedOlfactory sensory neurons connect to the antennal lobe of the fly to create the primary units for processing odor cues, the glomeruli. Unique amongst antennal-lobe neurons is an identified wide-field serotonergic...
- 2From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedSugars are important nutrients for many animals, but are also proposed to contribute to overnutrition-derived metabolic diseases in humans. Understanding the genetic factors governing dietary sugar tolerance therefore...
- 3From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedPlants react to pathogen attack via recognition of, and response to, pathogen-specific molecules at the cell surface and inside the cell. Pathogen effectors (virulence factors) are monitored by intracellular...
- 4From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedSenataxin, mutated in the human genetic disorder ataxia with oculomotor apraxia type 2 (AOA2), plays an important role in maintaining genome integrity by coordination of transcription, DNA replication, and the DNA...
- 5From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedSalmonella enterica serovar Agona has caused multiple food-borne outbreaks of gastroenteritis since it was first isolated in 1952. We analyzed the genomes of 73 isolates from global sources, comparing five distinct...
- 6From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedH1 linker histones facilitate higher-order chromatin folding and are essential for mammalian development. To achieve high-resolution mapping of H1 variants H1d and H1c in embryonic stem cells (ESCs), we have established...
- 7From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedIn all sexual organisms, adaptations exist that secure the safe reassortment of homologous alleles and prevent the intrusion of potentially hazardous alien DNA. Some bacteria engage in a simple form of sex known as...
- 8From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedAncient population structure shaping contemporary genetic variation has been recently appreciated and has important implications regarding our understanding of the structure of modern human genomes. We identified a...
- 9From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedThe PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase, and pinkl mutations cause early onset Parkinson's disease (PD) in humans. Loss of pinkl in Drosophila leads to defects in mitochondrial function, and genetic...
- 10From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedRecent results indicate that genome-wide association studies (GWAS) have the potential to explain much of the heritability of common complex phenotypes, but methods are lacking to reliably identify the remaining...
- 11From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedCholesterol availability is rate-limiting for myelination, and prior studies have established the importance of cholesterol synthesis by oligodendrocytes for normal CNS myelination. However, the contribution of...
- 12From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedThe mediators of the DNA damage response (DDR) are highly phosphorylated by kinases that control cell proliferation, but little is known about the role of this regulation. Here we show that cell cycle phosphorylation of...
- 13From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedIn prokaryotes, clustered regularly interspaced short palindromic repeats (CRISPRs) and their associated (Cas) proteins constitute a defence system against bacteriophages and plasmids. CRISPR/Cas systems acquire short...
- 14From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedX inactivation--the transcriptional silencing of one X chromosome copy per female somatic cell--is universal among therian mammals, yet the choice of which X to silence exhibits considerable variation among species. X...
- 15From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedThe fitness effect of mutations can be influenced by their interactions with the environment, other mutations, or both. Previously, we constructed 32 (= [2.sup.5]) genotypes that comprise all possible combinations of...
- 16From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedGene fusions, like BCR/ABL1 in chronic myelogenous leukemia, have long been recognized in hematologic and mesenchymal malignancies. The recent finding of gene fusions in prostate and lung cancers has motivated the...
- 17From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedEpigenetic variation, such as heritable changes of DNA methylation, can affect gene expression and thus phenotypes, but examples of natural epimutations are few and little is known about their stability and frequency in...
- 18From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedTraits that are attractive to the opposite sex are often positively correlated when scaled such that scores increase with attractiveness, and this correlation typically has a genetic component. Such traits can be...
- 19From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedHistone variants, including histone H2A.Z, are incorporated into specific genomic sites and participate in transcription regulation. The role of H2A.Z at these sites remains poorly characterized. Our study investigates...
- 20From: PLoS Genetics. (Vol. 9, Issue 4) Peer-ReviewedAlkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues. Although base excision repair (BER) is...