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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 9AndIssue Number: 4AndStart Page: e1003293AndDate: 2013 Revise Search
- 1From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedImmunodominance is a fundamental property of [CD8.sup.+] T cell responses to viruses and vaccines. It had been observed that route of administration alters immunodominance after vaccinia virus (VACV) infection, but only...
- 2From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedCryptococcus neoformans is the most common cause of fungal meningitis, with high mortality and morbidity. The reason for the frequent occurrence of Cryptococcus infection in the central nervous system (CNS) is poorly...
- 3From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedProgrammed cell death is characterized by a cascade of tightly controlled events that culminate in the orchestrated death of the cell. In multicellular organisms autophagy and apoptosis are recognized as two principal...
- 4From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedWhooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite the introduction of safer acellular pertussis vaccines (Pa). One explanation for this is that Pa are less protective than the...
- 5From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-Reviewed
Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes global epidemics of a debilitating polyarthritis in humans. As there is a pressing need for the development of therapeutic agents, we screened... - 6From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedTo cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets...
- 7From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedThe IL-27R, WSX-1, is required to limit IFN-[gamma] production by effector [CD4.sup.+] T cells in a number of different inflammatory conditions but the molecular basis of WSX-1-mediated regulation of Th1 responses in...
- 8From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedThe fungal cell wall is the first point of interaction between an invading fungal pathogen and the host immune system. The outer layer of the cell wall is comprised of GPI anchored proteins, which are...
- 9From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedDuring the first trimester of pregnancy the uterus is massively infiltrated by decidual natural killer cells (dNK). These cells are not killers, but they rather provide a microenvironment that is propitious to healthy...
- 10From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedMutation of DNA damage checkpoint signaling kinases ataxia telangiectasiamutated (ATM) or ATM- and Rad3-related (ATR) results in genomic instability disorders. However, it is not well understood how the instability...
- 11From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedYersinia pestis causes pneumonic plague, a disease characterized by inflammation, necrosis and rapid bacterial growth which together cause acute lung congestion and lethality. The bacterial type III secretion system...
- 12From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedThe intracellular parasite Theileria is the only eukaryote known to transform its mammalian host cells. We investigated the host mechanisms involved in parasite-induced transformation phenotypes. Tumour progression is a...
- 13From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedLJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations ([IC.sub.50][less than or equal to]0.5 [micro]M), and was posited to exploit the...
- 14From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedIn response to extra- or intracellular stresses, the cellular gatekeeper p53 is able to integrate multiple diverse signals to determine the outcome of cell fate, by regulating the expression of numerous responsive genes...
- 15From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedIn most organisms, the heat-shock response involves increased heat-shock gene transcription. In Kinetoplastid protists, however, virtually all control of gene expression is post-transcriptional. Correspondingly,...
- 16From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedPorphyromonas gingivalis is a major pathogen in severe and chronic manifestations of periodontal disease, which is one of the most common infections of humans. A central feature of P. gingivalis pathogenicity is...
- 17From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedHuman T-lymphotropic Virus-1 (HTLV-1) is a retrovirus that persists lifelong by driving clonal proliferation of infected T-cells. HTLV-1 causes a neuroinflammatory disease and adult T-cell leukemia/lymphoma....
- 18From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedThe Co-Evolution of Helminths and the Mammalian Immune System Helminth is a nonphylogenetic term that refers to multicellular animals (or metazoans) that have adopted a parasitic lifestyle in mammalian hosts. They...
- 19From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedThe [beta]-glucan receptor Dectin-1 is a member of the C-type lectin family and functions as an innate pattern recognition receptor in antifungal immunity. In both mouse and man, Dectin-1 has been found to play an...
- 20From: PLoS Pathogens. (Vol. 9, Issue 4) Peer-ReviewedChemotaxis enhances the fitness of Salmonella enterica serotype Typhimurium (S. Typhimurium) during colitis. However, the chemotaxis receptors conferring this fitness advantage and their cognate signals generated during...