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- 1From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedAbstract | The recent crop of results from genome-wide association studies might seem like a sudden development. However, this blooming follows a long germination period during which the necessary concepts, resources and...
- 2From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedThe ability of heat-shock protein 90 (HSP90) to mask genetic polymorphisms and reveal them only in times of environmental instability has attracted attention because of its potential to mediate rapid evolutionary change....
- 3From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedIn expression QTL (eQTL) analysis, individuals are genotyped across a panel of genetic markers and phenotyped using DNA microarrays. But finely mapping the genes that are responsible for changes in downstream expression...
- 4From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedChromosome positioning is thought to expose genomic loci to functionally distinct regions of the nucleus, generating transcriptional regulatory domains that favour either activation or repression. For example, components...
- 5From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedAbstract | Mouse genetics has made crucial contributions to the understanding of the molecular mechanisms of hearing. With the help of a plethora of mouse mutants, many of the key genes that are involved in the...
- 6From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedAbstract | The rapid accumulation of complete genomic sequences offers the opportunity to carry out an analysis of inter- and intea-individual genome variation within a species on a routine basis. Sequencing whole...
- 7From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedAt fertilization, male and female mammalian gametes contribute not only different genomes to the developing embryo, but different epigenetic modifications as well. The maternal genome is characterized by a nucleosomal...
- 8From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedIn this study the authors analysed the genetic and molecular bases for body pigmentation differences between two closely related fruitfly species: Drosophila yakuba and Drosophila santomea. They show that the expression...
- 9From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedPerhaps more than any other biological science, genetics is underpinned by concepts that are more abstract than the actual genes, cells, organisms and populations that it describes. In this respect, genetics shares much...
- 10From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedThis paper describes the development of resources for finescale mapping in Drosophila melanogaster using SNPs. The authors generated a map of 27,367 SNPs in widely used D. melanogaster stocks, with an average density of...
- 11From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedA remarkable study has pinpointed the gene involved in a rare form of epilepsy using data from only three affected individuals. Action myoclonus-renal failure syndrome (AMRF) is a very rare, recessively inherited form...
- 12From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedGenetic interactions provide important clues about functional interactions, but what exactly is a genetic interaction? These authors looked at four competing definitions, based on the fitness of yeast double mutants. In...
- 13From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedCorrect regulation of the process by which stem cells start differentiating is crucial to normal development and to the avoidance of cancer. Two new studies show the importance of specific microRNAs (miRNAs) in the...
- 14From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedThe availability of high-density SNP panels and effective genotyping platforms has done wonders for human population genetics. The same now promises to be true for livestock. One paper reports an approach to maximize SNP...
- 15From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedThis paper describes the first genome-wide maps of nucleosome positioning, using human CD4' T cells. The authors combined micrococcal nuclease-mediated digestion -a traditional means of identifying nucleosome...
- 16From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedAbstract | Heritability allows a comparison of the relative importance of genes and environment to the variation of traits within and across populations. The concept of heritability and its definition as an estimable,...
- 17From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedMetazoan gene-regulatory sequences can be situated far from transcription start sites, making it hard to assign biological functions to putative cis-regulatory elements (CREs). Warner et al. tackled this problem by first...
- 18From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedWhether a gene is active or silent depends on a sequence-specific interaction between transcription factors and cis-regulatory modules (CRMs). A new genome-wide study in Drosophila melanogaster embryos reveals that...
- 19From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedMonozygotic (MZ) twins have been widely used in studies of human disease, endophenotypes, gene expression and gene-environment interactions. MZ twins are generally assumed to be genetically identical, although some...
- 20From: Nature Reviews Genetics. (Vol. 9, Issue 4) Peer-ReviewedAbstract | Understanding the factors that determine the rate at which genomes generate and fix mutations provides important insights into key evolutionary mechanisms. We review our current knowledge of the rates of...