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- 1From: The Pharmacogenomics Journal. (Vol. 9, Issue 4) Peer-ReviewedWe examined whether two functional polymorphisms (g.-1562C > T and g.-90(CA)14-24) in the matrix metallo-proteinase (MMP)-9 gene or MMP-9 haplotypes affect the circulating levels of pro-MMP-9 and pro-MMP-9/TIMP-1 (tissue...
- 2From: The Pharmacogenomics Journal. (Vol. 9, Issue 4) Peer-ReviewedWeight gain, a serious problem associated with some antipsychotic drugs, notably olanzapine and clozapine, was suggested to be associated with -759C/T polymorphism of the 5-HT2C receptor gene. This study aimed to examine...
- 3From: The Pharmacogenomics Journal. (Vol. 9, Issue 4) Peer-ReviewedWe have studied the global frequency distributions of 10 single nucleotide polymorphisms (SNPs) across 132 kb of CYP2C8 and CYP2C9 in ~2500 individuals representing 45 populations. Five of the SNPs were in non-coding...
- 4From: The Pharmacogenomics Journal. (Vol. 9, Issue 4) Peer-ReviewedPolymorphisms in the CHRNA4 gene coding the nicotinic acetylcholine receptor subunit α4 have recently been suggested to play a role in the determination of smoking-related phenotypes. To examine this hypothesis, we...
- 5From: The Pharmacogenomics Journal. (Vol. 9, Issue 4) Peer-ReviewedThe selective estrogen receptor modulator tamoxifen is routinely used for treatment and prevention of estrogen-receptor-positive breast cancer. Studies of tamoxifen adherence suggest that over half of patients...
- 6From: The Pharmacogenomics Journal. (Vol. 9, Issue 4) Peer-ReviewedThe objective of the Genome-based Therapeutic Drugs for Depression study is to investigate the function of variations in genes encoding key proteins in serotonin, norepinephrine, neurotrophic and glucocorticoid signaling...
- 7From: The Pharmacogenomics Journal. (Vol. 9, Issue 4) Peer-ReviewedCytochrome P450 2A6 (CYP2A6) is the primary human enzyme involved in nicotine metabolism. The objective of this study was to characterize two nonsynonymous single nucleotide polymorphisms in CYP2A6*24, 594G4C (Val110Leu)...
- 8From: The Pharmacogenomics Journal. (Vol. 9, Issue 4) Peer-ReviewedPublished studies investigating the role of APOE gene on lipid response (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides) to statin...
- 9From: The Pharmacogenomics Journal. (Vol. 9, Issue 4) Peer-ReviewedThe organic cation transporter 1, encoded by the SLC22A1 gene, is responsible for the uptake of the anti-hyperglycaemic drug, metformin, in the hepatocyte. We assessed whether a genetic variation in the SLC22A1 gene is...