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- Search Terms:ISSN: 17594758AndISSN: 17594766AndVolume Number: 9AndIssue Number: 2AndStart Page: 118AndDate: 2013 Revise Search
- 1From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedThe neural pathways and brain regions involved in eye movements during ocular fixation and gaze control include the cerebrum, brainstem and cerebellum, and abnormal eye movements can indicate the presence of...
- 2From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedIn 2012, researchers published extensively on the genetic and clinicopathological characterization of patients with the newly discovered C9ORF72 repeat expansions, which cause amyotrophic lateral sclerosis (ALS) and...
- 3From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedApolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants of Alzheimer disease (AD) risk:...
- 4From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedA team in Canada has shown that the signalling protein Wnt7a improves muscle strength in the mdx mouse, an animal model of Duchenne muscular dystrophy (DMD). The action of Wnt7a in this context seems to be twofold: the...
- 5From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedAn article by Alex Leff and David Howard in the November issue of Nature Reviews Neurology (Stroke: Has speech and language therapy been shown not to work? Nat. Rev. Neurol. 8, 600-601) (1) discusses our recent article...
- 6From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedTransplantation of stem cells to replace degenerating dopaminergic neurons is an attractive therapeutic option for Parkinson disease (PD), but has so far had limited success in patients. A recent study in macaques has...
- 7From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-Reviewed"One small nibble for a woman, one giant bite for BCI." This was Jan Scheuermann's reaction to her new-found ability to guide a chocolate bar to her mouth via a brain-computer interface (BCI)-controlled robotic arm. The...
- 8From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedPrevious reports have indicated that mutations in the FUS/TLS gene account for 0.6-6.0% of familial amyotrophic lateral sclerosis (FALS) cases. In a recent study, Albert Ludolph and colleagues found a higher frequency...
- 9From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedTwo recent studies have shown that the pro-neurotrophin receptor sortilin regulates processing of amyloid-[beta] (A[beta]) --a key neurotoxic peptide in Alzheimer disease. Gustafsen et al. found that sortilin binds...
- 10From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedThe Alzheimer disease drug memantine has been used off-label to treat frontotemporal lobar degeneration (FLD). However, a recent double-blind, placebo-controlled trial involving 81 patients with FLD found that 26 weeks...
- 11From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedThe IL-12/IL-23 signalling pathway seems to contribute to the disease process in Alzheimer disease (AD) and could represent a novel therapeutic target, a study published in Nature Medicine indicates. Blockade of this...
- 12From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedIn 2012, studies of autosomal dominant Alzheimer disease (AD), late-onset AD, and a rare genetic mutation of amyloid precursor protein provided support for the critical role of amyloid in AD pathogenesis. Increasing...
- 13From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedSeveral clinical trials and experimental studies that could have a major impact on the treatment of patients with ischaemic stroke were published in 2012. The studies cover all therapeutic options, including stroke...
- 14From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedResearch on epilepsies in 2012 has substantially advanced our knowledge of these often devastating conditions. From important discoveries that revealed causative factors and the molecular basis of disease, to major...
- 15From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-Reviewed2012 witnessed important developments for multiple sclerosis, including successful phase III trials of novel oral therapeutics and identification of the potassium channel KIR4.1 as an autoimmune target. Additionally,...
- 16From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedTransient amnesic syndromes are striking clinical phenomena that are commonly encountered by physicians in acute medical settings. Diagnosis of such syndromes can be challenging, and their causes have been debated for...
- 17From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedA 55-gene blood transcriptional signature, ASD55, can distinguish children with autism spectrum disorders (ASD) from controls, according to new research. In an all-male sample cohort (66 with ASD and 33 controls), ASD55...
- 18From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedThe aetiology of Parkinson disease (PD) is known to include environmental factors such as exposure to toxins, but precisely how such factors lead to the characteristic degeneration of dopaminergic neurons in the...
- 19From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedDystonia type 4 (DYT4), or 'whispering dysphonia', is one of the few genetically linked dystonic disorders for which no locus or gene had been identified. Now, two studies published in Annals of Neurology have used...
- 20From: Nature Reviews Neurology. (Vol. 9, Issue 2) Peer-ReviewedTreatments for Alzheimer disease (AD) have largely targeted soluble amyloid-[beta] (A[beta])--the hallmark pathological protein in this disorder--despite the fact that deposited A[beta] is thought to initiate the...