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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 9AndIssue Number: 2AndStart Page: e1003196AndDate: 2013 Revise Search
- 1From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedAs one of the largest protein families, protein kinases (PKs) regulate nearly all processes within the cell and are considered important drug targets. Much research has been conducted on inhibitors for PKs, leading to a...
- 2From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedIn bacteria, laterally acquired genes are often concentrated within chromosomal regions known as genomic islands. Using a recently developed zebrafish infection model, we set out to identify unique factors encoded...
- 3From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedPlacental malaria (PM) can lead to poor neonatal outcomes, including low birthweight due to fetal growth restriction (FGR), especially when associated with local inflammation (intervillositis or IV). The pathogenesis of...
- 4From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedInfluenza virus has the ability to evade host immune surveillance through rapid viral genetic drift and reassortment; therefore, it remains a continuous public health threat. The development of vaccines producing...
- 5From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedLow-cost DNA sequencing has greatly democratized genomics, especially for the typically very small genomes of viruses [1-3]. The recent acceleration in human virus discovery by metagenomics indicates that many viruses...
- 6From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedPolymorphonuclear neutrophils (PMNs) are the first line of defense against microbial pathogens. In addition to their role in innate immunity, PMNs may also regulate events related to adaptive immunity. To investigate...
- 7From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedHantaviruses are among the most important zoonotic pathogens of humans and the subject of heightened global attention. Despite the importance of hantaviruses for public health, there is no consensus on their...
- 8From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedIn bacteria, transformation and restriction-modification (R-M) systems play potentially antagonistic roles. While the former, proposed as a form of sexuality, relies on internalized foreign DNA to create genetic...
- 9From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedEmergence of Prion Diseases Prion diseases are infectious, potentially zoonotic neurodegenerative diseases of animals including humans that are inevitably fatal and are caused by prions. Prions are comprised of a...
- 10From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedArthropod-borne pathogens account for millions of deaths each year. Understanding the genetic mechanisms controlling vector susceptibility to pathogens has profound implications for developing novel strategies for...
- 11From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedTo explore the role of [p16.sup.INK4a] as an intrinsic barrier to B cell transformation by EBV, we transformed primary B cells from an individual homozygous for a deletion in the CDKN2A locus encoding [p16.sup.INK4a]...
- 12From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedThe control and prevention of communicable disease is directly impacted by the genetic mutability of the underlying etiological agents. In the case of RNA viruses, genetic recombination may impact public health by...
- 13From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedEhrlichia chaffeensis is a tick transmitted pathogen responsible for the disease human monocytic ehrlichiosis. Research to elucidate gene function in rickettsial pathogens is limited by the lack of genetic manipulation...
- 14From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedIntroduction Inflammasomes are cytosolic, multiprotein complexes assembled by members of the NOD-like receptor (NLR) and PYHIN protein families in response to pathogen-associated molecular patterns (PAMPs) and danger...
- 15From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedStaphylococcus aureus contains an autoinducing quorum-sensing system encoded within the agr operon that coordinates expression of virulence genes required for invasive infection. Allelic variation within agr has...
- 16From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedHIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of resting memory [CD4.sup.+] T...
- 17From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedOverview In their struggle to survive and thrive, all living things must defend themselves from predatory attack. Microbes, in the form of parasites, bacteria, fungi, and viruses, are life's most accomplished...
- 18From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedLarge-scale codon re-encoding represents a powerful method of attenuating viruses to generate safe and cost-effective vaccines. In contrast to specific approaches of codon re-encoding which modify genome-scale...
- 19From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedThe actions of the RIG-I like receptor (RLR) and type I interferon (IFN) signaling pathways are essential for a protective innate immune response against the emerging flavivirus West Nile virus (WNV). In mice lacking...
- 20From: PLoS Pathogens. (Vol. 9, Issue 2) Peer-ReviewedThe majority of HIV-1 infections in women occur through vaginal intercourse, in which virus-containing semen is deposited on the cervico-vaginal mucosa. Semen is more than a mere carrier of HIV-1, since it contains many...