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- 1From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedThe mechanisms by which thymocytes commit to becoming CD[4.sup.+] T cells and how these cells subsequently can adopt various cell fates are becoming important paradigms of developmental programming. Understanding how...
- 2From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedHoyer, K.K. et al. Blood 113, 389-395 (2008) With the discovery of T helper 17 ([T.sub.H]17) cells, the examination of the role of different [T.sub.H]-cell subsets in autoimmunity has been a topic of great interest. In...
- 3From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedVeldhoen, M. et al. J. Exp. Med. 29 Dec 2009 (doi:10.1084/jem.20081438) Owing to the relevance of T helper 17 ([T.sub.H]17) cells in several autoimmune and inflammatory diseases, efforts are being made to characterize...
- 4From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedInterleukin-12 (IL-12) and IL-4 induce T helper 1 ([T.sub.H]1)- and [T.sub.H]2-cell differentiation, respectively, in vitro. However, not all [T.sub.H]1-cell responses require IL-12 in vivo, and [T.sub.H]2-cell responses...
- 5From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedWriting in Nature Immunology in June 2006, Robert Coffman--who together with Timothy Mossman was one of the founding fathers of the [T.sub.H]1-[T.sub.H]2-cell hypothesis --expressed his expectation that ultimately "the...
- 6From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedRegulatory T ([T.sub.Reg]) cells constitute a unique T-cell lineage that has a crucial role in immunological tolerance. Several years ago, forkhead box P3 (FOXP3) was identified as the transcription factor that was...
- 7From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedIt has been established that there is an enrichment of T helper 17 ([T.sub.H]17) cells in the intestine, but the molecular basis of this tissue tropism is not fully understood. Now, a study published in Mucosal...
- 8From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedQuirion, M. R. et al. J. Immunol. 182, 741-745 (2009) The transcription factor Ikaros is a key regulator of haematopoiesis and early lymphocyte development. Now, Quirion et al. have identified a regulatory role for...
- 9From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedFollowing antigen uptake by dendritic cells (DCs) in the periphery, the cells migrate to the lymph nodes where they can present the antigen to T cells. But how is antigen presentation coordinated with cell motility?...
- 10From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedThe disappointing recent news reporting the failure of a recombinant adenovirus serotype 5 (rAd5) vector-based vaccine to control HIV-1 infection caused researchers to question the viability of T-cell-based vaccines...
- 11From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedNaive CD[4.sup.+] T cells give rise to T-helper-cell subsets with functions that are tailored to their respective roles in host defence. The specification of T-helper-cell subsets is controlled by networks of...
- 12From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedA new study in Nature Medicine provides an explanation for a vaccine failure that occurred nearly 50 years ago, with fatal consequences. A formalin-inactivated vaccine against respiratory syncytial virus (RSV) that was...
- 13From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedRecent research has uncovered complex transcription factor networks that control the processes of T-cell development and differentiation. RUNX (runt-related transcription factor) proteins are among the many factors that...
- 14From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedTraditionally, natural killer (NK) cells have been considered to be part of the innate immune system. However, recent work has indicated that NK cells may have more traits in common with cells of the adaptive immune...
- 15From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedA report published in Nature Immunology has characterized the signalling pathways by which dendritic cells (DCs) induce adaptive immunity to fungal infections following stimulation of the C-type lectin receptor dectin 1....
- 16From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedStudies of osteopontin (OPN)-dependent regulation of immune responses have focused on the cytokine activities of the secreted form of this protein. Recent evidence has revealed that an intracellular form of OPN expressed...
- 17From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedNew research published in Nature Immunology shows that the costimulatory molecule ICOS (inducible T-cell co-stimulator) participates in amplifying responses of two CD4+ T-cell subsets--T helper 17 ([T.sub.H]17) cells and...
- 18From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedMany advances in our understanding of the molecules that regulate the development, differentiation and function of T cells have been made over the past few years. One important regulator of T-cell differentiation is the...
- 19From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedT helper 17 ([T.sub.H]17) cells are described as "two-for-one" effector T cells in a recent paper in Immunity. Casey Weaver and colleagues show that the [T.sub.H]17-cell lineage can shift from the production of...
- 20From: Nature Reviews Immunology. (Vol. 9, Issue 2) Peer-ReviewedUnderstanding the factors that are involved in the differentiation of T helper 17 ([T.sub.H]17) cells is currently one of the most active areas of immunological research. Now, Kopf and colleagues add more detail to this...