Showing Results for
- Academic Journals (25)
Search Results
- 25
Academic Journals
- 25
- Search Terms:
- 1From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedBasophils, the least abundant granulocytes, have poorly understood functions. They have been linked to the development of T helper type 2 immunity during parasite infection and allergic inflammation. Emerging evidence...
- 2From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedRecent studies suggest that nuclear factor κB-inducing kinase (NIK) is suppressed through constitutive proteasome-mediated degradation regulated by TRAF2, TRAF3 and cIAP1 or cIAP2. Here we demonstrated that the...
- 3From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedThe perennial appeal of immunology lies in the fact that it provides a window for almost every aspect of biological and biomedical research. The plasticity of lymphocytes as they switch among quiescence, active...
- 4From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedSince the discovery of T helper type 1 and type 2 effector T cell subsets 20 years ago, inducible regulatory T cells and interleukin 17 (IL-17)-producing T helper cells have been added to the 'portfolio' of helper T...
- 5From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedThe adaptor and signaling proteins TRAF2, TRAF3, cIAP1 and cIAP2 may inhibit alternative nuclear factor-κB (NF-κB) signaling in resting cells by targeting NF-κB-inducing kinase (NIK) for ubiquitin-dependent degradation,...
- 6From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedThe immune system senses invasion by viruses and mounts antiviral responses for eliminating the infection using pattern-recognition receptors that discriminate self and viral components (1,2). In contrast to mammals, in...
- 7From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedFoxo transcription factors regulate many developmental, metabolic and survival pathways. Foxo protein stability and cellular localization are regulated by the phosphatidylinositol-3-OH kinase and protein kinase B (Akt)...
- 8From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedMice lacking the coinhibitory molecule CTLA-4, expressed on conventional T cells after activation but constitutively on Foxp[3.sup.+] regulatory T ([T.sub.reg]) cells, develop fatal multiorgan inflammation. In Science,...
- 9From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedDrosophila, like other invertebrates and plants, relies mainly on RNA interference for its defense against viruses. In flies, viral infection also triggers the expression of many genes. One of the genes induced, Vago,...
- 10From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedIn February 2008, Nature Immunology and the Max Planck Institute hosted a T cell colloquium at the Ringberg Castle in Germany. This meeting highlighted some of the challenges now faced by T cell biologists (1). Defining...
- 11From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedThe year 2008 has seen more outbreaks of mumps and measles in the USA, Canada, and UK, among other Western countries. Both diseases had been almost completely eradicated in the Western hemisphere before the 1990s because...
- 12From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedToll-like receptors (TLRs) activate the innate immune system in response to pathogens. Here we show that TLR9 proteolytic cleavage is a prerequisite for TLR9 signaling. Inhibition of lysosomal proteolysis rendered TLR9...
- 13From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedThe survival of transitional and mature B cells requires both the B cell antigen receptor (BCR) and BLyS receptor 3 (BR3), which suggests that these receptors send signals that are nonredundant or that engage in...
- 14From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedMembers of the tumor necrosis factor-nerve growth factor (TNF-NGF) receptor 'superfamily' mediate their numerous effects on cell function by initiating changes in gene expression, for which they signal by activating...
- 15From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedTranscription factor Foxp3 is critical for generating regulatory T cells ([T.sub.reg] cells). Transforming growth factor-β (TGF-β) induces Foxp3 and suppressive [T.sub.reg] cells from naive T cells, whereas interleukin 6...
- 16From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedStudies have suggested that migratory dendritic cells (DCs) transport antigen to lymph nodes (LNs), where it is 'passed' to LN-resident DCs to mediate T cell activation. In Immunity, Laufer and colleagues determine that...
- 17From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedDuring variable-(diversity)-joining recombination, developing lymphocytes temporarily have double-stranded DNA breaks (DSBs) introduced by recombination-activating gene (RAG) products. In Nature, Sleckman and colleagues...
- 18From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedNedd4 and Itch are E3 ubiquitin ligases that ubiquitinate similar targets in vitro and thus are thought to function similarly. T cells lacking Itch show spontaneous activation and T helper type 2 polarization. To test...
- 19From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedThe transcription factors Foxo1, Foxo3 and Foxo4 modulate cell fate 'decisions' in diverse systems. Here we show that Foxo1-dependent gene expression was critical at many stages of B cell differentiation. Early deletion...
- 20From: Nature Immunology. (Vol. 9, Issue 12) Peer-ReviewedPlants protect themselves from potential pathogens by expressing receptor kinases that function as pattern-recognition receptors to confer innate immunity. In PLoS Biology, Park et al. identify in rice serine-threonine...