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- 1From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedThe mitochondrial inner membrane is the central energy-converting membrane of eukaryotic cells. The electrochemical proton gradient generated by the respiratory chain drives the ATP synthase. To maintain this...
- 2From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedThe first female meiotic division (meiosis I, MI) is uniquely prone to chromosome segregation errors through non-disjunction, resulting in trisomies and early pregnancy loss (1). Here, we show a fundamental difference in...
- 3From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedIn the letter by Miyanari et al. (Nature Cell Biol. 9, 1089-1097), Kunitada Shimotohno's affiliations were incorrectly listed. His affiliations should have been listed as 1, 2 and 6. (1) Department of Viral Oncology,...
- 4From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedAutophagy is an evolutionarily conserved 'self-eating' process. Although the genes essential for autophagy (named Atg) have been identified in yeast, the molecular mechanism of how Atg proteins control autophagosome...
- 5From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedEnzymes that mediate reversible epigenetic modifications have not only been recognized as key in regulating gene expression (1) and oncogenesis (2,3), but also provide potential targets for molecular therapy (4)....
- 6From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedIn Drosophila, the function of the Polycomb group genes (PcGs) and their target sequences (Polycomb response elements (PREs)) is to convey mitotic heritability of transcription programmes--in particular, gene silencing....
- 7From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedActin filaments are major components of at least 15 distinct structures in metazoan cells. These filaments assemble from a common pool of actin monomers, but do so at different times and places, and in response to...
- 8From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedMitosis in vertebrates involves nuclear-envelope breakdown and dispersal. On completion of chromatid segregation, disassembled nuclear-envelope components are reused to form nuclear membranes in the two daughter cells,...
- 9From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedThe transcription factor Hand1 is required for cell-fate determination during placental development. Recent work shows that release of Hand1 from the nucleolus controls differentiation of trophoblast stem cells into...
- 10From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedPoly(ADP-ribose) polymerase 1 (PARP-1) and p53 are two key proteins in the DNA-damage response. Although PARP-1 is known to poly(ADP-ribosyl)ate p53, the role of this modification remains elusive. Here, we identify the...
- 11From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedJuggling the demands of a career and a family is a challenge that confronts many researchers. Are universities doing enough to help academics cope with these often-conflicting commitments. ********** Few professions...
- 12From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedThe class III phosphatidylinositol 3-kinase (PI(3)KC3) is part of a key complex regulating autophagy. How this complex mechanistically contributes to autophagosome formation remains largely unknown. The...
- 13From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedThe formation of the nuclear envelope (NE) around chromatin is a major membrane-remodelling event that occurs during cell division of metazoa. It is unclear whether the nuclear membrane reforms by the fusion of NE...
- 14From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedThe idea that microRNAs have a hand in tumour development has been further cemented with the finding that miRNA-10b is upregulated by Twist to drive breast cancer cell invasion and metastasis through effects on HoxD10...
- 15From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedEukaryotic cells employ autophagy to degrade damaged or obsolete organelles and proteins. Central to this process is the formation of autophagosomes, double-membrane vesicles responsible for delivering cytoplasmic...
- 16From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-Reviewed
A proteomic screen reveals [SCF.sup.Grr1] targets that regulate the glycolytic-gluconeogenic switch.
Entry into the cell cycle is regulated by nutrient availability such that cells do not divide when resources are limited. The Skp1-Cul1-F-box (SCF) ubiquitin ligase with the F-box protein Grr1 ([SCF.sup.Grr1]) controls... - 17From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedThe neurofibromatosis-2 (NF2) tumour-suppressor gene encodes an intracellular membrane-associated protein, called merlin, whose growth-suppressive function is dependent on its ability to form interactions through its...
- 18From: Nature Cell Biology. (Vol. 9, Issue 10) Peer-ReviewedThe bHLH transcription factor Hand1 is essential for placentation and cardiac morphogenesis in the developing embryo. Here we implicate Hand1 as a molecular switch that determines whether a trophoblast stem cell...