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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 9AndIssue Number: 1AndStart Page: e1003137AndDate: 2013 Revise Search
- 1From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedIn the past few years, case-control studies of common diseases have shifted their focus from single genes to whole exomes. New sequencing technologies now routinely detect hundreds of thousands of sequence variants in a...
- 2From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedResearchers have long been enthralled with the idea that gene duplication can generate novel functions, crediting this process with great evolutionary importance. Empirical data shows that whole-genome duplications...
- 3From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedTelomeres are protein-DNA structures found at the ends of linear chromosomes and are crucial for genome integrity. Telomeric DNA length is primarily maintained by the enzyme telomerase. Cells lacking telomerase will...
- 4From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedMolting, or the replacement of the old exoskeleton with a new cuticle, is a complex developmental process that all insects must undergo to allow unhindered growth and development. Prior to each molt, the developing new...
- 5From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedAdenocarcinoma (AC) and squamous cell carcinoma (SqCC) are two major histological subtypes of lung cancer. Genome-wide association studies (GWAS) have made considerable advances in the understanding of lung cancer...
- 6From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedThe coordination of subcellular processes during adaptation to environmental change is a key feature of biological systems. Starvation of essential nutrients slows cell cycling and ultimately causes G1 arrest, and...
- 7From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedMini-chromosome maintenance (MCM) 2-9 proteins are related helicases. The first six, MCM2-7, are essential for DNA replication in all eukaryotes. In contrast, MCM8 is not always conserved in eukaryotes but is present in...
- 8From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedLow-oxygen tolerance is supported by an adaptive response that includes a coordinate shift in metabolism and the activation of a transcriptional program that is driven by the hypoxia-inducible factor (HIF) pathway. The...
- 9From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedA critical step in the assembly of the neural circuits that control tetrapod locomotion is the specification of the lateral motor column (LMC), a diverse motor neuron population targeting limb musculature. Hox6 paralog...
- 10From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedThe telomere-ending binding protein complex CST (Cdc13-Stn1-Ten1) mediates critical functions in both telomere protection and replication. We devised a co-expression and affinity purification strategy for isolating...
- 11From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedR2 retrotransposable elements exclusively insert into the tandemly repeated rRNA genes, the rDNA loci, of their animal hosts. R2 elements form stable long-term associations with their host, in which all individuals in a...
- 12From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedHistone lysine methylation is an important epigenetic modification in regulating chromatin structure and gene expression. Histone H3 lysine 4 methylation (H3K4me), which can be in a mono-, di-, or trimethylated state,...
- 13From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedGenome integrity depends on correct chromosome segregation, which in turn relies on cohesion between sister chromatids from S phase until anaphase. S phase cohesion, together with DNA double-strand break (DSB)...
- 14From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedMastermind-like 1 (MAML1) is a transcriptional co-activator in the Notch signaling pathway. Recently, however, several reports revealed novel and unique roles for MAML1 that are independent of the Notch signaling...
- 15From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedAmong the pantheon of computer scientists who have framed our capacity to interpret DNA sequences stands David Haussler of the University of California, Santa Cruz (UCSC). Applying his prowess in computer learning...
- 16From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedSecondary metabolism and development are linked in Aspergillus through the conserved regulatory velvet complex composed of VeA, VelB, and LaeA. The founding member of the velvet complex, VeA, shuttles between the...
- 17From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedIntense selective pressures applied over short evolutionary time have resulted in homogeneity within, but substantial variation among, horse breeds. Utilizing this population structure, 744 individuals from 33 breeds,...
- 18From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedIn the bacterial world, methylation is most commonly associated with restriction-modification systems that provide a defense mechanism against invading foreign genomes. In addition, it is known that methylation plays...
- 19From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedThe mechanisms that guide motile sperm through the female reproductive tract to oocytes are not well understood. We have shown that Caenorhabditis elegans oocytes synthesize sperm guiding F-series prostaglandins from...
- 20From: PLoS Genetics. (Vol. 9, Issue 1) Peer-ReviewedAccurate chromosome segregation requires centromeres (CENs), the DNA sequences where kinetochores form, to attach chromosomes to microtubules. In contrast to most eukaryotes, which have broad centromeres, Saccharomyces...