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- 1From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedWe investigate the dynamics of a deterministic finite-sized network of synaptically coupled spiking neurons and present a formalism for computing the network statistics in a perturbative expansion. The small parameter...
- 2From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedAbnormalities in glycan biosynthesis have been conclusively linked to many diseases but the complexity of glycosylation has hindered the analysis of glycan data in order to identify glycoforms contributing to disease....
- 3From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedThe crab Cancer borealis undergoes large daily fluctuations in environmental temperature (8-24[degrees]C) and must maintain appropriate neural function in the face of this perturbation. In the pyloric circuit of the...
- 4From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedFlocks of starlings exhibit a remarkable ability to maintain cohesion as a group in highly uncertain environments and with limited, noisy information. Recent work demonstrated that individual starlings within large...
- 5From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedThe epidemiology of chronic viral infections, such as those caused by Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV), is affected by the risk group structure of the infected population. Risk groups are...
- 6From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedThe information processing abilities of neural circuits arise from their synaptic connection patterns. Understanding the laws governing these connectivity patterns is essential for understanding brain function. The...
- 7From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedNature has shaped the make up of proteins since their appearance, ~3.8 billion years ago. However, the fundamental drivers of structural change responsible for the extraordinary diversity of proteins have yet to be...
- 8From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedHigh-throughput technologies produce massive amounts of data. However, individual methods yield data specific to the technique used and biological setup. The integration of such diverse data is necessary for the...
- 9From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedIt is well established that individuals age differently. Yet the nature of these inter-individual differences is still largely unknown. For humans, two main hypotheses have been recently formulated: individuals may...
- 10From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedMetabolomics is a relatively new "omics" platform, which analyzes a discrete set of metabolites detected in bio-fluids or tissue samples of organisms. It has been used in a diverse array of studies to detect biomarkers...
- 11From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedA key hypothesis in sensory system neuroscience is that sensory representations are adapted to the statistical regularities in sensory signals and thereby incorporate knowledge about the outside world. Supporting this...
- 12From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedIn recent years, the field of network science has enabled researchers to represent the highly complex interactions in the brain in an approachable yet quantitative manner. One exciting finding since the advent of brain...
- 13From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-Reviewed
Durable resistance to crop pathogens: an epidemiological framework to predict risk under uncertainty
Increasing the durability of crop resistance to plant pathogens is one of the key goals of virulence management. Despite the recognition of the importance of demographic and environmental stochasticity on the dynamics... - 14From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedMany infections can be transmitted between animals and humans. The epidemiological roles of different species can vary from important reservoirs to dead-end hosts. Here, we present a method to identify transmission...
- 15From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedCopper (Cu) is an important enzyme co-factor that is also extremely toxic at high intracellular concentrations, making active efflux mechanisms essential for preventing Cu accumulation. Here, we have investigated the...
- 16From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedAnkyrin repeat proteins are elastic materials that unfold and refold sequentially, repeat by repeat, under force. Herein we use atomistic molecular dynamics to compare the mechanical properties of the 7-ankyrin-repeat...
- 17From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedAdvances in computational metabolic optimization are required to realize the full potential of new in vivo metabolic engineering technologies by bridging the gap between computational design and strain development. We...
- 18From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedTo understand the complex relationship governing transcript abundance and the level of the encoded protein, we integrate genome-wide experimental data of ribosomal density on mRNAs with a novel stochastic model...
- 19From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedYou finished your PhD, have been a postdoc for a while, and you start wondering, "What's next?" Suppose you come to the conclusion that you want to stay in academia, and move up the ladder to become a principal...
- 20From: PLoS Computational Biology. (Vol. 9, Issue 1) Peer-ReviewedDivisive normalization in primary visual cortex has been linked to adaptation to natural image statistics in accordance to Barlow's redundancy reduction hypothesis. Using recent advances in natural image modeling, we...