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- 1From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedThis is an in-depth review of the history of quinacrine as well as its pharmacokinetic properties and established record of safety as an FDA-approved drug. The potential uses of quinacrine as an anti-cancer agent are...
- 2From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedIntroduction TGF-[beta] signaling has been extensively studied in many developmental contexts, amongst which is its ability to induce epithelial to mesenchymal transitions (EMT). EMTs play crucial roles during...
- 3From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedIntroduction Non-transformed mammary epithelial cell lines such as MCF-10A recapitulate epithelial morphogenesis in three-dimensional (3D) tissue culture by forming acinar structures. They represent an important tool...
- 4From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedPost-translational modification of proteins at serine and threonine side chains by [beta]-N-acetylglucosamine (O-GlcNAc) mediated by the enzyme [beta]-N-acetylglucosamine transferase has been emerging as a fundamental...
- 5From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedBackground [alpha].sub.2 -adrenergic receptors (ARs) mediate many cellular actions of epinephrine and norepinephrine and inhibit their secretion from adrenal chromaffin cells. Like many other G-protein coupled...
- 6From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedBackground The B cell antigen receptor (BCR) and pathogen recognition receptors, such as Toll-like receptor 4 (TLR4), act in concert to control adaptive B cell responses. However, little is known about the signaling...
- 7From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedSirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a wide variety of functions in biological...
- 8From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedRecent advances in tumor biology have revealed that a detailed analysis of the complex interactions of tumor cells with their adjacent microenvironment (tumor stroma) is mandatory in order to understand the various...
- 9From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedIn this study we investigated if and how cannabinoid receptor stimulation regulates macrophageal differentiation, which is one of the key steps in the immune effector reaction. For that reason, we used a well...
- 10From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedAuthors: Stephan M Feller (corresponding author) [1] Editorial The 14th annual gathering of the Signal Transduction Society (STS; http://www.sigtrans.de) brought together scientists from eleven different countries...
- 11From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedProtein phosphorylation participates in the regulation of all fundamental biological processes, and protein kinases have been intensively studied. However, while the focus was on catalytic activities, accumulating...
- 12From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedCalcium (Ca.sup.2+.sup.) homeostasis is fundamental for cell metabolism, proliferation, differentiation, and cell death. Elevation in intracellular Ca.sup.2+ .sup.concentration is dependent either on Ca.sup.2+...
- 13From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedStimulating the receptors of a single cell generates stochastic intracellular signaling. The fluctuating response has been attributed to the low abundance of signaling molecules and the spatio-temporal effects of...
- 14From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedBackground Host cell invasion by the foodborne pathogen Campylobacter jejuni is considered as one of the primary reasons of gut tissue damage, however, mechanisms and key factors involved in this process are widely...
- 15From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedVacA, the vacuolating cytotoxin A of Helicobacter pylori, induces apoptosis in epithelial cells of the gastic mucosa and in leukocytes. VacA is released by the bacteria as a protein of 88 kDa. At the outer surface of...
- 16From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedPhorbol ester (TPA) treatment of human U937 myeloid leukemia cells is associated with increasing adherence and monocyte-like maturation whereby the role of [beta].sub.2 integrin-mediated attachment for subsequent growth...
- 17From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedChanges in the intracellular calcium concentration govern cytoskeletal rearrangement, mitosis, apoptosis, transcriptional regulation or synaptic transmission, thereby, regulating cellular effector and organ functions....
- 18From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedEmbryonic stem cells (ESC) and induced pluripotent stem cells (iPSCs) present a great opportunity to treat and model human disease as a cell replacement therapy. There is a growing pressure to understand better the...
- 19From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedHelicobacter pylori is a highly successful pathogen uniquely adapted to colonize humans. Gastric infections with this bacterium can induce pathology ranging from chronic gastritis and peptic ulcers to gastric cancer....
- 20From: Cell Communication and Signaling. (Vol. 9) Peer-ReviewedThe mesenchymal stroma harbors an important population of cells that possess stem cell-like characteristics including self renewal and differentiation capacities and can be derived from a variety of different sources....