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- 1From: Hereditary Cancer in Clinical Practice. (Vol. 9) Peer-ReviewedThe BRCA1/2 genes account for a significant portion of hereditary breast and ovarian cancers and they are especially prevalent in the Ashkenazi Jewish population. Women who have a mutation can prevent breast and ovarian...
- 2From: Hereditary Cancer in Clinical Practice. (Vol. 9) Peer-ReviewedBackground Inheritance of a mutation in either BRCA1 or BRCA2 accounts for approximately 5% of all breast cancer cases, but varies by country. Investigations into the contribution of BRCA mutations to breast cancer...
- 3From: Hereditary Cancer in Clinical Practice. (Vol. 9) Peer-ReviewedAbout 5-10% of breast and ovarian carcinomas are hereditary and most of these result from germline mutations in the BRCA1 and BRCA2 genes. In women of Ashkenazi Jewish ascendance, up to 30% of breast and ovarian...
- 4From: Hereditary Cancer in Clinical Practice. (Vol. 9) Peer-ReviewedBackground Patients at higher than average risk of heritable cancer may process risk information differently than the general population. However, little is known about clinical, demographic, or psychosocial...
- 5From: Hereditary Cancer in Clinical Practice. (Vol. 9) Peer-ReviewedBackground Lynch syndrome is a hereditary cancer with confirmed carriers at high risk for colorectal (CRC) and extracolonic cancers. The purpose of the current study was to develop a greater understanding of the...
- 6From: Hereditary Cancer in Clinical Practice. (Vol. 9) Peer-ReviewedBackground Neurofibroma occurs as isolated or multiple lesions frequently associated with neurofibromatosis type 1 (NF1), a common autosomal dominant disorder affecting 1 in 3500 individuals. It is caused by...
- 7From: Hereditary Cancer in Clinical Practice. (Vol. 9) Peer-ReviewedBackground We assessed ovarian cancer screening outcomes in women with a positive family history of ovarian cancer divided into a low-, moderate- or high-risk group for development of ovarian cancer. Methods...
- 8From: Hereditary Cancer in Clinical Practice. (Vol. 9) Peer-ReviewedBackground The perception of breast cancer risk held by women who have not had breast cancer, and who are at increased, but unexplained, familial risk of breast cancer is poorly described. This study aims to describe...
- 9From: Hereditary Cancer in Clinical Practice. (Vol. 9) Peer-ReviewedBackground Risk perception is considered a motivating factor for adopting preventive behaviors. This study aimed to verify the demographic characteristics and cancer family history that are predictors of risk...
- 10From: Hereditary Cancer in Clinical Practice. (Vol. 9) Peer-ReviewedCarcinomas of the appendix are exceedingly rare tumors and have an annual age-adjusted incidence of around 0.4 cases per 100,000. Appendiceal adenocarcinoma accounts for [less than] 0.5% of all gastrointestinal...
- 11From: Hereditary Cancer in Clinical Practice. (Vol. 9) Peer-ReviewedTumors arising in patients with hereditary cancer syndromes may have distinct drug sensitivity as compared to their sporadic counterparts. Breast and ovarian neoplasms from BRCA1 or BRCA2 mutation carriers are...