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- 1From: Molecular Neurodegeneration. (Vol. 9) Peer-ReviewedPerturbed Endoplasmic Reticulum (ER) calcium (Ca.sup.2+) homeostasis emerges as a central player in Alzheimer disease (AD). Accordingly, different studies have reported alterations of the expression and the function of...
- 2From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedAuthor(s): Michael D Hoos1 , Michael P Vitek2 , Lisa A Ridnour3 , Joan Wilson2 , Marilyn Jansen2 , Angela Everhart2 , David A Wink3 and Carol A Colton2 Background The past five years have proven to be...
- 3From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedAlzheimer's disease (AD) is a neurodegenerative disorder in which the amyloid-[beta] (A[beta]) oligomers are a key factor in synaptic impairment and in spatial memory decline associated with neuronal dysfunction. This...
- 4From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedBackground Understanding how inflammation causes neuronal damage is of paramount importance in multiple sclerosis (MS) and in other neurodegenerative diseases. Here we addressed the role of the apoptotic cascade in...
- 5From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedAuthor(s): Meewhi Kim1,2 Findings An expansion of CAG-repeat encoding continuous stretch of glutamines results in polyQ expansion in the context of several proteins. These polyQ expansions are responsible for nine...
- 6From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedAuthor(s): Vez Repunte-Canonigo1 , Celine Lefebvre3 , Olivier George2 , Tomoya Kawamura1 , Marisela Morales4 , George F Koob2,5 , Andrea Califano6 , Eliezer Masliah7 and Pietro Paolo Sanna1 Background...
- 7From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedAuthor(s): Hongmei Li1,2 , Qinxi Guo1 , Taeko Inoue3 , Vinicia A Polito1 , Katsuhiko Tabuchi7 , Robert E Hammer4 , Robia G Pautler3 , George E Taffet1,5 and Hui Zheng1,6 Background Deposition of [beta]-amyloid...
- 8From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedBackground We recently found that brain tissue from patients with type-2 diabetes (T2D) and cognitive impairment contains deposits of amylin, an amyloidogenic hormone synthesized and co-secreted with insulin by...
- 9From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedBackground Central nervous system (CNS) trauma and neurodegenerative disorders trigger a cascade of cellular and molecular events resulting in neuronal apoptosis and regenerative failure. The pathogenic mechanisms...
- 10From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedBackground Familial British and Familial Danish dementias (FBD and FDD, respectively) are associated with mutations in the BRI.sub.2 gene. Processing of the mutated BRI.sub.2 protein leads to the accumulation in the...
- 11From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedAuthor(s): Christopher W Medway1 , Samer Abdul-Hay1 , Tynickwa Mims1 , Li Ma1 , Gina Bisceglio1 , Fanggeng Zou1 , Shane Pankratz2 , Sigrid B Sando3,4 , Jan O Aasly3,4 , Maria Barcikowska5 , Joanna Siuda1,6 , Zbigniew K...
- 12From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedAuthor(s): Xin Wang1,2 , Timothy Huang2 , Guojun Bu1 and Huaxi Xu1,2 Background Endocytic dysregulation is apparent in many neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD)...
- 13From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedBackground Synaptic degeneration is an early pathogenic event in Alzheimer's disease, associated with cognitive impairment and disease progression. Cerebrospinal fluid biomarkers reflecting synaptic integrity would...
- 14From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedBackground It is suspected that excess of brain cholesterol plays a role in Alzheimer's disease (AD). Membrane-associated cholesterol was shown to be increased in the brain of individuals with sporadic AD and to...
- 15From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedAuthor(s): Chadwick M Hales1,2 , Nicholas T Seyfried2,3 , Eric B Dammer2,3 , Duc Duong2 , Hong Yi4 , Marla Gearing5 , Juan C Troncoso6 , Elliott J Mufson7 , Madhav Thambisetty8 , Allan I Levey1,2 and James J Lah1,2...
- 16From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedAuthor(s): Scott Ayton1 , Peng Lei1 , Paul A Adlard1 , Irene Volitakis1 , Robert A Cherny1 , Ashley I Bush1 and David I Finkelstein1 Findings The substantia nigra pars compacta (SN) contains high iron and dopamine...
- 17From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedBackground Mounting evidence suggests that soluble oligomers of amyloid-[beta] (oA[beta]) represent the pertinent synaptotoxic form of A[beta] in sporadic Alzheimer's disease (AD); however, the mechanistic links...
- 18From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedAuthor(s): Shangtong Jiang1,2 , Yanfang Li2 , Xian Zhang2 , Guojun Bu2,3 , Huaxi Xu1,2,4 and Yun-wu Zhang2 Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized clinically by cognitive...
- 19From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedAuthor(s): Yi Li1 , Christopher Bohm2 , Roger Dodd1 , Fusheng Chen2 , Seema Qamar1 , Gerold Schmitt-Ulms2 , Paul E Fraser2 and Peter H St George-Hyslop1,2 Multiple lines of evidence suggest that the accumulation and...
- 20From: Molecular Neurodegeneration. (Vol. 9, Issue 1) Peer-ReviewedAuthor(s): Ekaterina Poguzhelskaya1,2 , Dmitry Artamonov1,2 , Anastasia Bolshakova1,2 , Olga Vlasova1,2 and Ilya Bezprozvanny1,2,3 Background Understanding structural organization of the brain is critical for...