Showing Results for
- Academic Journals (112)
Search Results
- 112
Academic Journals
- 112
- Search Terms:
- 1From: Retrovirology. (Vol. 9) Peer-ReviewedBackground The GNB3 C825T polymorphism is associated with increased G protein-mediated signal transduction, SDF-1[alpha]-mediated lymphocyte chemotaxis, accelerated HIV-1 progression, and altered responses to...
- 2From: Retrovirology. (Vol. 9) Peer-ReviewedAttenuation of p53 activity appears to be a major step in Human T-lymphotropic virus type 1 (HTLV-1) Tax transformation. However, p53 genomic mutations are late and rather infrequent events in HTLV-1 induced Adult T cell...
- 3From: Retrovirology. (Vol. 9) Peer-ReviewedBackground Retroviral Gag proteins are encoded in introns and, because of this localization, they are subject to the default pathways of pre-mRNA splicing. Retroviruses regulate splicing and translation through a...
- 4From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedBackground Current data suggest that an efficacious human immunodeficiency virus type 1 (HIV-1) vaccine should elicit both adaptive humoral and cell mediated immune responses. Such a vaccine will also need to protect...
- 5From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedBackground SAMHD1 is an HIV-1 restriction factor in non-dividing monocytes, dendritic cells (DCs), macrophages, and resting CD4.sup.+ T-cells. Acting as a deoxynucleoside triphosphate (dNTP) triphosphohydrolase,...
- 6From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedBackground The ribonuclease H (RNase H) domains of retroviral reverse transcriptases play an essential role in the replication cycle of retroviruses. During reverse transcription of the viral genomic RNA, an RNA/DNA...
- 7From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedBackground Certain post-translational modifications to histones, including H3K4me3, as well as binding sites for the transcription factor STAT1, predict the site of integration of exogenous gamma-retroviruses with...
- 8From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedBackground Processive elongation of the integrated HIV-1 provirus is dependent on recruitment of P-TEFb by the viral Tat protein to the viral TAR RNA element. P-TEFb kinase activity requires phosphorylation of Thr186...
- 9From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedBackground The recently approved anti-AIDS drug rilpivirine (TMC278, Edurant) is a nonnucleoside inhibitor (NNRTI) that binds to reverse transcriptase (RT) and allosterically blocks the chemical step of DNA...
- 10From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedHuman Immunodeficiency Virus (HIV) maturation plays an essential role in the viral life cycle by enabling the generation of mature infectious virus particles through proteolytic processing of the viral Gag and GagPol...
- 11From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedBackground Human T-cell leukemia virus types 1 and 2 (HTLV-1 and HTLV-2) are delta retroviruses with similar genetic organization. Although both viruses immortalize T-cells in vitro, they exhibit distinct pathogenic...
- 12From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedBackground The TAR hairpin is present at both the 5' and 3' end of the HIV-1 RNA genome. The 5' element binds the viral Tat protein and is essential for Tat-mediated activation of transcription. We recently observed...
- 13From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedThe importance of geographic diversity in publishing is emphasized in this editorial. Author(s): Kuan-Teh Jeang1 Earlier this year, I read about a remarkable change in the United States population. For the first...
- 14From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedBackground APOBEC3 proteins are host factors that restrict infection by retroviruses like HIV, MMTV, and MLV and are variably expressed in hematopoietic and non-hematopoietic cells, such as macrophages, lymphocytes,...
- 15From: Retrovirology. (Vol. 9) Peer-ReviewedBackground HIV-1 superinfection occurs at varying frequencies in different at risk populations. Though seroincidence is decreased, in the negative partner of HIV-discordant couples after joint testing and counseling...
- 16From: Retrovirology. (Vol. 9) Peer-ReviewedBackground Resistance to the fusion inhibitor enfuvirtide (ENF) is achieved by changes in the gp41 subunit of the HIV envelope glycoprotein (Env). Specific ENF-associated mutational pathways correlate with...
- 17From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedBackground The development of anaemia in feline leukaemia virus (FeLV)-infected cats is associated with the emergence of a novel viral subgroup, FeLV-C. FeLV-C arises from the subgroup that is transmitted, FeLV-A,...
- 18From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedBackground HIV latency is an obstacle for the eradication of HIV from infected individuals. Stable post-integration latency is controlled principally at the level of transcription. The HIV trans-activating protein,...
- 19From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedBackground The effect of drug resistance transmission on disease progression in the newly infected patient is not well understood. Major drug resistance mutations severely impair viral fitness in a drug free...
- 20From: Retrovirology. (Vol. 9, Issue 1) Peer-ReviewedBackground Quiescent CD4.sup.+ T lymphocytes are highly refractory to HIV-1 infection due to a block at reverse transcription. Results Examination of SAMHD1 expression in peripheral blood lymphocytes shows that...