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- 1From: Biochemistry and Cell Biology. (Vol. 87, Issue 5) Peer-ReviewedEpigenetic programming is an important facet of biology, controlling gene expression patterns and the choice between developmental pathways. The Polycomb group proteins (PcGs) silence gene expression, allowing cells to...
- 2From: Biochemistry and Cell Biology. (Vol. 87, Issue 5) Peer-ReviewedChromatin structure is important for the compaction of eukaryotic genomes, thus chromatin modifications play a fundamental role in regulating many cellular processes. The coordinated activities of various...
- 3From: Biochemistry and Cell Biology. (Vol. 87, Issue 5) Peer-ReviewedThere are a number of well-characterized and fundamental roles for noncoding RNAs (ncRNAs) in gene regulation in all kingdoms of life. ncRNAs, such as ribosomal RNAs, transfer RNAs, small nuclear RNAs, small nucleolar...
- 4From: Biochemistry and Cell Biology. (Vol. 87, Issue 5) Peer-ReviewedChromatin condensation and subsequent decondensation are processes required for proper execution of various cellular events. During mitosis, chromatin compaction is at its highest, whereas relaxation of chromatin is...
- 5From: Biochemistry and Cell Biology. (Vol. 87, Issue 5) Peer-ReviewedTelomeres, the natural ends of linear chromosomes, must be protected and completely replicated to guarantee genomic stability in eukaryotic cells. However, the protected state of telomeres is not compatible with...
- 6From: Biochemistry and Cell Biology. (Vol. 87, Issue 5) Peer-ReviewedThe [beta]-globin gene cluster in mammals, consisting of a set of erythroid-specific, developmentally activated, and (or) silenced genes, has long presented a model system for the investigation of gene regulation. As...
- 7From: Biochemistry and Cell Biology. (Vol. 87, Issue 5) Peer-ReviewedThere has been a hotbed of activity surrounding MeCP2 research in the past number of years. Despite better characterizing the functions and nature of this protein, it has become abundantly clear that MeCP2 is involved...
- 8From: Biochemistry and Cell Biology. (Vol. 87, Issue 5) Peer-ReviewedX-chromosome inactivation is a fascinating epigenetic phenomenon that is initiated by expression of a noncoding (nc)RNA, XIST, and results in transcriptional silencing of 1 female X. The process requires a series of...