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- 1From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedOver the past two decades, trials of citicoline for treatment of acute stroke have produced conflicting results. A recent large clinical trial of citicoline in acute stroke suggests a lack of efficacy of this therapy,...
- 2From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedMultiple sclerosis (MS) is an immune-mediated disease characterized by inflammatory demyelination and neurodegeneration within the CNS. This damage of CNS structures leads to deficits of body functions, which, in turn,...
- 3From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedAs temporal lobe epilepsy (TLE) is associated with abnormal localization of hippocampal granule cells, Koyama et al. investigated the mechanisms underlying granule cell ectopia. Using a rat model of complex febrile...
- 4From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedAn intensive neuropsychological rehabilitation programme, administered over a 3-month period to patients with relapsing-remitting multiple sclerosis (MS), provides improvements in cognitive functions and quality of life...
- 5From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedThe efforts of five independent research groups have identified mutations in the KCND3 gene that cause spinocerebellar ataxia (SCA) type 19 and type 22. The groups used a combination of genetic linkage analysis in...
- 6From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedRecent studies suggest that advances in medical therapy have reduced the risk of stroke in patients with major cerebral artery disease, but does this trend apply to those with misery perfusion? A new study indicates...
- 7From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedMutations in the sodium channel Na 1.7 that cause small fibre neuropathy (SFN) have variable functional effects on neurons, which might explain the variability of symptoms among patients with these disorders, according...
- 8From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedAn investigation into MRI outcomes in the FTY720 Research Evaluating Effects of Daily Oral Therapy in Multiple Sclerosis (FREEDOMS) trial has shown the beneficial effects of fingolimod in reducing inflammatory activity...
- 9From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedTranscriptome study in neurodegenerative disease has advanced considerably in the past 5 years. Increasing scientific rigour and improved analytical tools have led to more-reproducible data. Many transcriptome analysis...
- 10From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedA PET imaging study to detect microglial activation in patients with multiple sclerosis (MS) has found a direct correlation between cortical microglial activation and disease severity. Politis et al. compared binding of...
- 11From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedEEG source imaging (ESI) is a model-based imaging technique that integrates temporal and spatial components of EEG to identify the generating source of electrical potentials recorded on the scalp. Recent advances in...
- 12From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedFluoxetine, an antidepressant drug, has shown promise as a therapy in spinal cord injury (SCI), but the mechanism underlying this neuroprotection was unknown. Using a mouse contusion-injury model, Lee et al. show that...
- 13From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedIncreasing evidence suggests that early treatment is essential for efficacy of therapeutic intervention in neurodegenerative diseases such as Alzheimer disease (AD) and Parkinson disease (PD). Two new studies have...
- 14From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedGenetic risk factors that underlie many rare and common neurological disorders remain poorly understood because of the multifactorial and heterogeneous nature of these complex traits. With the decreasing cost of...
- 15From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedIn a recent study, published in Neurology, Edip Gurol et al. sought to determine whether MRI combined with Pittsburgh compound B (PiB)-PET could be used to predict the locations of future haemorrhages in patients with...
- 16From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedIn a whole-genome sequencing study of 1,795 Icelandic people, researchers have identified a coding variant in amyloid-[beta] ([beta]) precursor protein (APP) that protects against Alzheimer disease (AD) and cognitive...
- 17From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedResults from two recent studies have added to a growing body of evidence that supports the diagnostic utility of florbetapir, an [sup.18]F-labelled PET imaging biomarker of amyloid-[beta] (A[beta]), in patients with...
- 18From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedREM sleep behaviour disorder (RBD) is a parasomnia involving dream enactment, and is a prediagnostic sign of Parkinson disease (PD) and other synucleinopathies. A recent multicentre study has highlighted key risk...
- 19From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedUnderstanding how genetic variation can confer susceptibility to neurological disease is an urgent priority. A new gene-expression study has explored the relationship between DNA sequence variation at the...
- 20From: Nature Reviews Neurology. (Vol. 8, Issue 9) Peer-ReviewedHaematoma growth within the first 24 h following intracerebral haemorrhage (ICH) is associated with poor outcome. Delcourt et al. measured haematoma growth over 24 h in 335 patients with ICH, and assessed the link...