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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 8AndIssue Number: 9AndStart Page: e1002974AndDate: 2012 Revise Search
- 1From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedDiabetic nephropathy (DN) is associated with excess morbidity and mortality, in both type 1 (T1D) and type 2 (T2D) diabetic patients. Despite intensification of treatment, DN remains a growing problem worldwide [1-6]....
- 2From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedDomestication has led to similar changes in morphology and behavior in several animal species, raising the question whether similarities between different domestication events also exist at the molecular level. We used...
- 3From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedDomestic dogs can suffer from hearing losses that can have profound impacts on working ability and quality of life. We have identified a type of adult-onset hearing loss in Border Collies that appears to have a genetic...
- 4From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedRheumatoid arthritis is an autoimmune disease with a complex etiology, leading to inflammation of synovial tissue and joint destruction. Through a genome-wide association study (GWAS) and two replication studies in the...
- 5From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedThe homeodomain and adjacent CVC domain in the visual system homeobox (VSX) proteins are conserved from nematodes to humans. Humans with missense mutations in these regions of VSX2 have microphthalmia, suggesting both...
- 6From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedThe neural crest (NC) is a vertebrate-specific cell population that exhibits remarkable multipotency. Although derived from the neural plate border (NPB) ectoderm, cranial NC (CNC) cells contribute not only to the...
- 7From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedAlthough many of the questions raised by the discovery of imprinting have been answered, we have not yet accounted for tissue--or stage-specific imprinting. The Kcnq1 imprinted domain exhibits complex tissue-specific...
- 8From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedComplement C3 and C4 play key roles in the main physiological activities of complement system, and their deficiencies or over-expression are associated with many clinical infectious or immunity diseases. A two-stage...
- 9From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedThe benefits of ever-growing numbers of sequenced eukaryotic genomes will not be fully realized until we learn to decipher vast stretches of noncoding DNA, largely composed of transposable elements. Transposable...
- 10From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedBudding yeast centromeres are sequence-defined point centromeres and are, unlike in many other organisms, not embedded in heterochromatin. Here we show that Fun30, a poorly understood SWI/SNF-like chromatin remodeling...
- 11From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedHistone H3 di- and trimethylation on lysine 4 are major chromatin marks that correlate with active transcription. The influence of these modifications on transcription itself is, however, poorly understood. We have...
- 12From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedCell communication is essential for eukaryotic development, but our knowledge of molecules and mechanisms required for intercellular communication is fragmentary. In particular, the connection between signal sensing and...
- 13From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedThe emerging technology of massively parallel DNA sequencing has had a major impact on progress in genomics and personalized medicine [1]. Most recently, DNA sequencing of whole exomes (complete coding regions of the...
- 14From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedUTX (KDM6A) and UTY are homologous X and Y chromosome members of the Histone H3 Lysine 27 (H3K27) demethylase gene family. UTX can demethylate H3K27;however, in vitro assays suggest that human UTY has lost enzymatic...
- 15From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedIntragenomic conflicts arise when a genetic element favours its own transmission to the detriment of others. Conflicts over sex chromosome transmission are expected to have influenced genome structure, gene regulation,...
- 16From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedAdaptation is likely to be an important determinant of the success of many pathogens, for example when colonizing a new host species, when challenged by antibiotic treatment, or in governing the establishment and...
- 17From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedUsing a genome-wide screening approach, we have established the genetic requirements for proper telomere structure in Saccharomyces cerevisiae. We uncovered 112 genes, many of which have not previously been implicated...
- 18From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedMitochondria from diverse phyla, including protozoa, fungi, higher plants, and humans, import tRNAs from the cytosol in order to ensure proper mitochondrial translation. Despite the broad occurrence of this process, our...
- 19From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedPeripheral insulin resistance contributes to the development of type 2 diabetes. TCF7L2 has been tightly associated with this disease, although the exact mechanism was largely elusive. Here we propose a novel role of...
- 20From: PLoS Genetics. (Vol. 8, Issue 9) Peer-ReviewedReactive oxygen species (ROS) are toxic but essential molecules responsible for host defense and cellular signaling. Conserved NADPH oxidase (NOX) family enzymes direct the regulated production of ROS. Hydrogen peroxide...