Showing Results for
- Academic Journals (44)
Search Results
- 44
Academic Journals
- 44
- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 8AndIssue Number: 9AndStart Page: e1002913AndDate: 2012 Revise Search
- 1From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedMammalian target of rapamycin (mTOR) kinases are emerging as master regulators of cellular metabolism [1]. During an infection, pathogens seek nutrition to survive and often exploit host machinery that controls cellular...
- 2From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedVesicular stomatitis virus (VSV) suppresses antiviral responses in infected cells by inhibiting host gene expression at multiple levels, including transcription, nuclear cytoplasmic transport, and translation. The...
- 3From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedTwo classes of antiviral drugs, neuraminidase inhibitors and adamantanes, are approved for prophylaxis and therapy against influenza virus infections. A major concern is that antiviral resistant viruses emerge and...
- 4From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedDuring viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. in this study, we applied metabolic labeling of newly transcribed RNA with 4-thiouridine...
- 5From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedWolbachia endosymbionts carried by filarial nematodes give rise to the neglected diseases African river blindness and lymphatic filariasis afflicting millions worldwide. Here we identify new Wolbachia-disrupting...
- 6From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedWe Need New Antifungal Drugs Invasive fungal infections are devastating. Despite state-of-the-art antifungal therapy, the mortality rates for invasive infections with the three most common species of human fungal...
- 7From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedEpigenetic mechanisms are essential for the regulation of all genes in mammalian cells but transcriptional repression including DNA methylation are also major epigenetic mechanisms of defense inactivating potentially...
- 8From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedThe Vibrio cholerae lipopolysaccharide O1 antigen is a major target of bacteriophages and the human immune system and is of critical importance for vaccine design. We used an O1-specific lytic bacteriophage as a tool to...
- 9From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedHIV-1 infection of macrophages plays a key role in viral pathogenesis and progression to AIDS. Polyinosine- polycytidylic acid (poly(I:C);a synthetic analog of dsRNA) and bacterial lipopolysaccharide (LPS), the ligands...
- 10From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedTetherin (BST-2/CD317/HM1.24) is an IFN induced transmembrane protein that restricts release of a broad range of enveloped viruses. Important features required for Tetherin activity and regulation reside within the...
- 11From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedPlasmacytoid dendritic cells (pDCs) are the major producers of type I IFN in response to viral infection and have been shown to direct both innate and adaptive immune responses in vitro. However, in vivo evidence for...
- 12From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedRNA viruses typically occur in genetically diverse populations due to their error-prone genome replication. Genetic diversity is thought to be important in allowing RNA viruses to explore sequence space, facilitating...
- 13From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedKaposi's Sarcoma (KS), caused by Kaposi's Sarcoma Herpesvirus (KSHV), is a highly vascularised angiogenic tumor of endothelial cells, characterized by latently KSHV-infected spindle cells and a pronounced inflammatory...
- 14From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedIntroduction Copper (Cu) is a transition metal used by life from bacteria to eukaryotes in many cellular processes as a biochemical cofactor and a signaling molecule. However, while Cu plays critical cellular roles,...
- 15From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedSurface recognition and penetration are critical steps in the infection cycle of many plant pathogenic fungi. In Magnaporthe oryzae, cAMP signaling is involved in surface recognition and pathogenesis. Deletion of the...
- 16From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedIdentifying genomic elements required for viability is central to our understanding of the basic physiology of bacterial pathogens. Recently, the combination of high-density mutagenesis and deep sequencing has allowed...
- 17From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedDuring acute viral infections, clearance of the pathogen is followed by the contraction of the anti-viral T cell compartment. In contrast, T cell responses need to be maintained over a longer period of time during...
- 18From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedCationic antimicrobial peptides (CAMPs) serve as the first line of defense of the innate immune system against invading microbial pathogens. Gram-positive bacteria can resist CAMPs by modifying their anionic teichoic...
- 19From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedThe cellular endosomal sorting complex required for transport (ESCRT) machinery participates in membrane scission and cytoplasmic budding of many RNA viruses. Here, we found that expression of dominant negative ESCRT...
- 20From: PLoS Pathogens. (Vol. 8, Issue 9) Peer-ReviewedIntestinal inflammation changes the luminal habitat for microbes through mechanisms that have not been fully resolved. We noticed that the FepE regulator of very long O-antigen chain assembly in the enteric pathogen...