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- 1From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedRates of increase in the incidence of childhood type 1 diabetes mellitus (T1DM) have differed significantly between two 10-year periods from 1989 to 2008 in a number of European countries, a study published in...
- 2From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedGlobal and gene-specific changes in the epigenome are hallmarks of most tumour types, including those of pituitary origin. In contrast to genetic mutations, epigenetic changes (aberrant DNA methylation and histone...
- 3From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedNeither provision of basal insulin nor of n-3 fatty acids to patients with poor glycaemic control who are at a high risk of adverse cardiovascular events confers significant cardiovascular protection. These findings of...
- 4From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedThe incidence of osteoporosis induced by glucocorticoid treatment is second only to that owing to oestrogen deficiency. Treatment and prevention of glucocorticoid-induced osteoporosis are, however, problematic. Can a...
- 5From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedWhen insulin therapy is introduced in advanced stages of type 2 diabetes mellitus many patients are already being treated with metformin and continue to receive this oral antihyperglycaemic agent. In a systematic review...
- 6From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedTherapy for diabetes mellitus, especially with insulin, could increase the risk of lung cancer among postmenopausal women, according to the results of a new study. Association between diabetes mellitus therapy and...
- 7From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedHistorically, clinical management of patients with type 1 diabetes mellitus (T1DM) has been focused on glycaemic control, which is sometimes achieved at the expense of weight gain on intensive insulin regimes. Although...
- 8From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedA new study ascribes the known association between small birth size and development of the metabolic syndrome later in life to accelerated early postnatal weight gain. In the Journal of Clinical Endocrinology and...
- 9From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedLong-term biochemical control of acromegaly does not prevent progression of acromegalic arthropathy in many patients, report researchers from The Netherlands. Arthropathy is a complication of acromegaly that impairs...
- 10From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedThis Review covers the rationale, physiological consequences and clinical application of pharmacological sodium-glucose cotransporter 2 (SGLT2) inhibition. In patients with type 2 diabetes mellitus, in whom renal...
- 11From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedESRP1 is a candidate master regulator of epithelial-mesenchymal transition (EMT) in somatotroph adenomas, indicates a new study. Patients with somatotroph adenomas have excessive levels of circulating growth hormone,...
- 12From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedWe read the Review article written by Andrew S. Papadopoulos and Anthony J. Cleare (Papadopoulos, A. S. & Cleare, A. J. Hypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome. Nat. Rev. Endocrinol....
- 13From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedElevated levels of methylglyoxal--a precursor of advanced glycation end products--in patients with diabetes mellitus induce hyperalgesia in diabetic neuropathy through post-translational modifications of the...
- 14From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedTwo multinational, randomized, open-label studies published in The Lancet shed light on the pros and cons of different second-line agents for the treatment of patients with type 2 diabetes mellitus (T2DM) inadequately...
- 15From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedIn 149 newly diagnosed patients with pituitary microadenoma, Mathioudakis et al. report significantly increased prevalence of central hypothyroidism (18%) in patients with ACTH-secreting microadenomas compared with...
- 16From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedReducing gestational weight gain is possible and may avoid some obstetric, perinatal and long-term metabolic risks for the mother and offspring. Reducing gestational weight gain, however, is not a panacea for all...
- 17From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedThe long-term survival of patients with thyroid cancer and the possibility of tumour recurrence up to 30-40 years after the achievement of a disease-free status illustrate the importance of lifelong follow-up in these...
- 18From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedThe majority of infectious exacerbations of cystic fibrosis (CF) in women occur at times of high circulating levels of oestradiol, report researchers from Ireland. A sex dichotomy exists in the disease severity of CF....
- 19From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedA meta-regression analysis of data from 22 reports with a total of 4,206 patients who had Roux-en-Y gastric bypass (RYGB) surgery shows that weight loss is maintained for >2 years after surgery. RYGB surgery was...
- 20From: Nature Reviews Endocrinology. (Vol. 8, Issue 8) Peer-ReviewedAspirin use increases the risk of serious bleeding in the general population, but not in patients with diabetes mellitus, suggest the results of a new study. Low-dose aspirin therapy is widely used to prevent adverse...