Showing Results for
- Academic Journals (77)
Search Results
- 77
Academic Journals
- 77
- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 8AndIssue Number: 8AndStart Page: e1002890AndDate: 2012 Revise Search
- 1From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedGermline mutations of the Liver Kinase bl (LKB1/STK11) tumor suppressor gene have been linked to Peutz-Jeghers Syndrome (PJS), an autosomal-dominant, cancer-prone disorder in which patients develop neoplasms in several...
- 2From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedUnderstanding the genetic mechanisms underlying complex traits is one of the next frontiers in biology. The budding yeast Saccharomyces cerevisiae has become an important model for elucidating the mechanisms that govern...
- 3From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedStructural genetic changes, especially copy number variants (CNVs), represent a major source of genetic variation contributing to human disease. Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital...
- 4From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedThe zebrafish is a powerful experimental system for uncovering gene function in vertebrate organisms. Nevertheless, studies in the zebrafish have been limited by the approaches available for eliminating gene function....
- 5From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedIn human diploid cells, 23 pairs of chromosomes become recognizable as a discrete set of rod-shaped entities during the mitotic stage of the cell cycle. Upon exit from mitosis, they decondense and are packed together...
- 6From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedTranscript elongation by RNA polymerase II (RNAPII) is accompanied by conserved patterns of histone modification. Whereas histone modifications have established roles in transcription initiation, their functions during...
- 7From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedNormal development of the respiratory system is essential for survival and is regulated by multiple genes and signaling pathways. Both Tbx4 and Tbx5 are expressed throughout the mesenchyme of the developing lung and...
- 8From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedLinker histones are essential components of chromatin, but the distributions and functions of many during cellular differentiation are not well understood. Here, we show that H1.5 binds to genic and intergenic regions,...
- 9From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedAlthough the SLX4 complex, which includes structure-specific nucleases such as XPF, MUS81, and SLX1, plays important roles in the repair of several kinds of DNA damage, the function of SLX1 in the germline remains...
- 10From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedDNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is...
- 11From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedNuclear export of mRNAs and pre-ribosomal subunits (pre40S and pre60S) is fundamental to all eukaryotes. While genetic approaches in budding yeast have identified bona fide export factors for mRNAs and pre60S subunits,...
- 12From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedA key challenge in the production of second generation biofuels is the conversion of lignocellulosic substrates into fermentable sugars. Enzymes, particularly those from fungi, are a central part of this process, and...
- 13From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedThe decision to replicate its DNA is of crucial importance for every cell and, in many organisms, is decisive for the progression through the entire cell cycle. A comparison of animals versus yeast has shown that,...
- 14From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedThe zebrafish adult pigment pattern has emerged as a useful model for understanding the development and evolution of adult form as well as pattern-forming mechanisms more generally. In this species, a series of...
- 15From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedMeiosis is a specialized eukaryotic cell division that generates haploid gametes required for sexual reproduction. During meiosis, homologous chromosomes pair and undergo reciprocal genetic exchange, termed crossover...
- 16From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedMany cells in a developing embryo, including neurons and their axons and growth cones, must integrate multiple guidance cues to undergo directed growth and migration. The UNC-6/netrin, SLT-1/slit, and VAB-2/Ephrin...
- 17From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedThe discovery that somatic cells are reprogrammable to pluripotency by ectopic expression of a small subset of transcription factors has created great potential for the development of broadly applicable stem-cell-based...
- 18From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedThe phenotypic effect of a gene is normally described by the mean-difference between alternative genotypes. A gene may, however, also influence the phenotype by causing a difference in variance between genotypes. Here,...
- 19From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedOsteoporosis is a common polygenic disease and global healthcare priority but its genetic basis remains largely unknown. We report a high-throughput multi-parameter phenotype screen to identify functionally significant...
- 20From: PLoS Genetics. (Vol. 8, Issue 8) Peer-ReviewedDegeneration of synaptic and axonal compartments of neurons is an early event contributing to the pathogenesis of many neurodegenerative diseases, but the underlying molecular mechanisms remain unclear. Here, we...