Showing Results for
- Academic Journals (23)
Search Results
- 23
Academic Journals
- 23
- Search Terms:
- 1From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedAbstract I The principal components of both MHC class I and class II antigen processing and presentation pathways are well known. In dendritic cells, these pathways are tightly regulated by Toll-like-receptor signalling...
- 2From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedExperimental autoimmune encephalomyelitis (EAE), which is used as a mouse model of multiple sclerosis, was initially described as an interleukin-12 (IL-12)-driven T helper 1 ([T.sub.H]1)-cell-mediated disease. However,...
- 3From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedIn many types of immune responses, ???T cells have unique and non-redundant roles, but the aspects of their development and function are not as well characterized as those of αβ T cells. Now, Chien and colleagues...
- 4From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedMoir, S. et al. J. Exp. Med. 14 July 2008 (doi:10.1084/jem.20072683) In this study, Moir et al. describe a population of [CD20.sup.hi][CD21.sup.low][CD27.sup.-]B cells (similar to a population found in human tonsillar...
- 5From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedNorthrop, J. K., Wells, A. D. & Shen, H. J. Immunol. 181, 865-868 (2008) Memory [CD8.sup.+] T cells are characterized by their rapid responsiveness to secondary stimulation. However, such a responsive state is not...
- 6From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedAbstract | Although often encoding fewer than a dozen genes, RNAviruses can overcome host antiviral responses and wreak havoc on the cells they infect. Some manage to evade host antiviral defences, whereas others elicit...
- 7From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedShaffer, A. L. et al. Nature 454, 226-231 (2008) Using a recently developed screening method to identify therapeutic targets in cancer, Shaffer et al. describe interferon-regulatory factor 4 (IRF4) as a master...
- 8From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-Reviewed[CD8.sub.+] T cells are known to be crucial for protection against the intracellular parasite Toxoplasma gondii. But the parasite-derived peptides that are recognized by the protective T cells have remained elusive. Now,...
- 9From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedAbstract | WNT proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many...
- 10From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedThe neutrophil-derived serine proteases proteinase-3 (encoded by PRTN3) and neutrophil elastase (encoded by ELA2) are implicated in antibacterial defence, but they also contribute to tissue damage and noninfectious...
- 11From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedTown, T. et al. Nature Med. 14, 681-687 (2008) Despite chronic activation of innate immune cells in the brains of subjects with Alzheimer's disease, microglial cells ultimately fail to clear the build up of amyloid-β...
- 12From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedHuard, B. et al. J. Clin. Invest. 10 July 2008 (doi:10.1172/JCI33760) Long-lived plasma cells reside in the bone marrow, where their survival factors have been characterized, or in mucosa-associated lymphoid tissue...
- 13From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedGiven the well-established role of the pre-B-cell receptor (pre-BCR) in the positive selection of B cells, it comes as a surprise to learn that the pre-BCR also has a role in negative selection. A new study published in...
- 14From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedLipids, in particular cholesterol, are generally considered unfavourably in terms of our health, but cholesterol is an essential component of cell membranes and is required for cell growth and proliferation. Does...
- 15From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedAbstract | Members of the TIM (T-cell immunoglobulin domain and mucin domain) protein family are emerging as important regulators of immune responses. As their names imply, the TIM proteins were originally thought to be...
- 16From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedAbstract | The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the urgent need to refocus on the question of which T-cell responses are required to control HIV replication. The...
- 17From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedOn 22 May 2008, the Federation of American Scientists (FAS), in collaboration with Brown University, the University of Southern California and Escape Hatch Entertainment, launched Immune Attack, a three-dimensional...
- 18From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedTwo new studies in Nature Immunology have uncovered a mechanism of innate immune activation that might underlie conditions such as Alzheimer's disease and silicosis, a progressive lung illness caused by the inhalation of...
- 19From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedAbstract | Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection. This function of pDCs is linked...
- 20From: Nature Reviews Immunology. (Vol. 8, Issue 8) Peer-ReviewedSteinberg, M. W. et al. J. Exp. Med. 205, 1463-1476 (2008) The tumour-necrosis factor receptor superfamily member HVEM (herpesvirus entry mediator) can mediate either pro- or anti-inflammatory effects, owing to its...