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- 1From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedThe Human Combinatorial Antibody Library (HuCAL) was screened for antibodies specific to human leukocyte antigen-DR (HLA-DR) that induce programmed death of lymphoma/leukemia cells expressing the target antigen. The...
- 2From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedThe placenta provides an immune shield for the foreign body inside a pregnant woman--the fetus. The placenta secretes immunosuppressive molecules and otherwise counters the mom's immune system at the maternal-placental...
- 3From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedBoth enteroviral infection of the heart and mutations in the dystrophin gene can cause cardiomyopathy. Little is known, however, about the interaction between genetic and acquired forms of cardiomyopathy. We previously...
- 4From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedEfforts to control vessel growth have focused on vascular endothelial growth factor (VEGF) and its primary receptor VEGFR-2. New data could shift that focus to other members of the VEGF family and the receptor VEGFR-1,...
- 5From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedEditors at the New England Journal of Medicine have retracted a paper published in 1998 against the wishes of the authors because it is believed to contain a doctored version of a figure published by another group, in...
- 6From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedBefore leaving the body, cholesterol is converted to bile acids. Two studies implicate the nuclear receptor SHP as a major player in bile-acid production--but not the only one. Maintaining a balance of cholesterol in...
- 7From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedThe mechanism by which angiogenic factors recruit bone marrow (BM)-derived quiescent endothelial and hematopoietic stem cells (HSCs) is not known. Here, we report that functional vascular endothelial growth factor...
- 8From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedMurine antibodies that block cell-surface antigens have been engineered (humanized) to successfully elicit human immune-effector mechanisms. Now, a fully human antibody produced entirely in vitro kills tumor cells...
- 9From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedAdvanced Targeting Systems has introduced Hum-ZAP--a chemical conjugate of affinity-purified goat anti-human IgG and the ribosome-inactivating protein, saporin. HumZAP is a second immunotoxin that uses a secondary...
- 10From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedThailand, the host of the next World AIDS conference in 2004, has had some success in dealing with its HIV epidemic. 1.2 million of the country's 62 million population is HIV positive and there are 30,000 to 50,000 new...
- 11From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedBD Biosciences offers a new three-dimensional (3D) calcium phosphate scaffold--a mineralized calcium phosphate bioceramic that is intended for in vitro and in vivo analysis of bone metabolism. Additionally, data...
- 12From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedThe neurotransmitter dopamine underlies most addictive processes--but its faint response to ethanol has puzzled researchers. New research suggests that ethanol interacts synergistically with adenosine and dopamine...
- 13From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedWe recently isolated a Kruppel-like zinc-finger transcription factor 5 (KLF5; also known as BTEB2 and IKLF), which is markedly induced in activated vascular smooth-muscle cells and fibroblasts. Here we describe our...
- 14From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedA major concern in cancer therapy is resistance of tumors such as glioblastoma to current treatment protocols. Here, we report that transfer of the gene encoding second mitochondria-derived activator of caspase (Smac)...
- 15From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedIf you want to be the ace in the big game then don't shave off the last two hours of sleep. That's one implication of a study by Walker et al. who showed that a good night's sleep improves learning of motor tasks. In...
- 16From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedWithin days of the vote to ban somatic-cell nuclear transfer (SCNT) being defeated, Senator Sam Brownback tried another tack, proposing instead to ban patents on SCNT-derived material. Many believe the new proposal is...
- 17From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedNon-invasive imaging and transcriptional targeting can improve the safety of therapeutic approaches in cancer. Here we demonstrate the ability to identify metastases in a human-prostate cancer model, employing a...
- 18From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedB7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in the regulation of cellular and humoral immune responses through the PD-1 receptor on activated T and B cells....
- 19From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedThe Lyme disease vaccine is based on the outer-surface lipoprotein (OspA) of the pathogen Borrelia burgdorferi, and 95% of vaccine recipients develop substantial titers of antibodies against OspA. Here, we identified...
- 20From: Nature Medicine. (Vol. 8, Issue 8) Peer-ReviewedBeckman Coulter's Biomek FX assay workstation is a new system for the complete automation of ELISAs and homogeneous biological assays. The workstation, based on the flexible Biomek FX liquid handling platform, features...