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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 8AndIssue Number: 7AndStart Page: e1002815AndDate: 2012 Revise Search
- 1From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedRNA splicing is a major regulatory mechanism for controlling eukaryotic gene expression. By generating various splice isoforms from a single pre-mRNA, alternative splicing plays a key role in promoting the evolving...
- 2From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedConjugative transfer of the integrative and conjugative element ICEclc in the bacterium Pseudomonas knackmussii is the consequence of a bistable decision taken in some 3% of cells in a population during stationary...
- 3From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedLevels of G1 cyclins fluctuate in response to environmental cues and couple mitotic signaling to cell cycle entry. The G1 cyclin Cln3 is a key regulator of cell size and cell cycle entry in budding yeast. Cln3...
- 4From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedGenome-wide association studies (GWAS) have revolutionized human genetics. They have led to the identification of thousands of loci that affect both normal variation and susceptibility to disease, and have clarified our...
- 5From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedRegulation of PCNA ubiquitylation plays a key role in the tolerance to DNA damage in eukaryotes. Although the evolutionary conserved mechanism of PCNA ubiquitylation is well understood, the deubiquitylation of ubPCNA...
- 6From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedIn the last few years, two paradigms underlying human evolution have crumbled. Modern humans have not totally replaced previous hominins without any admixture, and the expected signatures of adaptations to new...
- 7From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedBRCA1 promotes DNA repair through interactions with multiple proteins, including CtIP and FANCJ (also known as BRIP17 BACH1). While CtIP facilitates DNA end resection when de-acetylated, the function of FANCJ in repair...
- 8From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedThe unfolded protein response (UPR) is a conserved mechanism that mitigates accumulation of unfolded proteins in the ER. The yeast UPR is subject to intricate post-transcriptional regulation, involving recruitment of...
- 9From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedThe relationship between epigenetic marks on chromatin and the regulation of DNA replication is poorly understood. Mutations of the H3K27 methyltransferase genes, ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and...
- 10From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedThe mammalian odorant receptor (OR) repertoire is an attractive model to study evolution, because ORs have been subjected to rapid evolution between species, presumably caused by changes of the olfactory system to adapt...
- 11From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedSex chromosome dosage compensation in Drosophila provides a model for understanding how chromatin organization can modulate coordinate gene regulation. Male Drosophila increase the transcript levels of genes on the...
- 12From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedAnimals acquire predictive values of sensory stimuli through reinforcement. In the brain of Drosophila melanogaster, activation of two types of dopamine neurons in the PAM and PPL1 clusters has been shown to induce...
- 13From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedThe sexual Fus3 MAP kinase module of yeast is highly conserved in eukaryotes and transmits external signals from the plasma membrane to the nucleus. We show here that the module of the filamentous fungus Aspergillus...
- 14From: PLoS Genetics. (Vol. 8, Issue 7) Peer-Reviewed
The [SCF.sup.Dia2] ubiquitin E3 ligase ubiquitylates Sir4 and functions in transcriptional silencing
In budding yeast, transcriptional silencing, which is important to regulate gene expression and maintain genome integrity, requires silent information regulator (Sir) proteins. In addition, Rtt106, a histone chaperone... - 15From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedSex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases...
- 16From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedInterorgan lipid transport occurs via lipoproteins, and altered lipoprotein levels correlate with metabolic disease. However, precisely how lipoproteins affect tissue lipid composition has not been comprehensively...
- 17From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedWe use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide...
- 18From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedDuring nervous system development, neuronal cell bodies and their axodendritic projections are precisely positioned through transiently expressed patterning cues. We show here that two neuronally expressed, secreted...
- 19From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedTo identify genetic loci influencing bone accrual, we performed a genome-wide association scan for total-body bone mineral density (TB-BMD) variation in 2,660 children of different ethnicities. We discovered variants in...
- 20From: PLoS Genetics. (Vol. 8, Issue 7) Peer-ReviewedIn Drosophila melanogaster, cis-regulatory modules that are activated by the Notch cell-cell signaling pathway all contain two types of transcription factor binding sites: those for the pathway's transducing factor...