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Academic Journals
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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 8AndIssue Number: 7AndStart Page: e1002803AndDate: 2012 Revise Search
- 1From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedHIV-1 infection begins with the binding of trimeric viral envelope glycoproteins (Env) to CD4 and a co-receptor on target T-cells. Understanding how these ligands influence the structure of Env is of fundamental...
- 2From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedEnterovirus 71 (EV71) is one of the most virulent enteroviruses, but the specific molecular features that enhance its ability to disseminate in humans remain unknown. We analyzed the genomic features of EV71 in an...
- 3From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedIntroduction and Basic Biology The microsporidia are obligate intracellular parasites that were previously thought to be "primitive" eukaryotes, but which are now recognized to be either related to or a sister group...
- 4From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedThe DNA deaminase APOBEC3G converts cytosines to uracils in retroviral cDNA, which are immortalized as genomic strand G-to-A hypermutations by reverse transcription. A single round of APOBEC3G-dependent mutagenesis can...
- 5From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedType I interferons (IFN-I) broadly control innate immunity and are typically transcriptionally induced by Interferon Regulatory Factors (IRFs) following stimulation of pattern recognition receptors within the cytosol of...
- 6From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedPseudomonas aeruginosa strain PA14 is an opportunistic human pathogen capable of infecting a wide range of organisms including the nematode Caenorhabditis elegans. We used a non-redundant transposon mutant library...
- 7From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedHepatitis C virus (HCV) infects over 170 million people worldwide and is the leading cause of chronic liver diseases, including cirrhosis, liver failure, and liver cancer. Available antiviral therapies cause severe side...
- 8From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedUbiquitin (Ub) is a vital regulatory component in various cellular processes, including cellular responses to viral infection. As obligate intracellular pathogens, viruses have the capacity to manipulate the ubiquitin...
- 9From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedIL-10 is a critical regulatory cytokine involved in the pathogenesis of visceral leishmaniasis caused by Leishmania donovani and clinical and experimental data indicate that disease progression is associated with...
- 10From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedTwo recently emerged cutaneous fungal diseases of wildlife, bat white-nose syndrome (WNS) [1] and amphibian chytridiomycosis [2], have devastated affected populations. Fungal diseases are gaining recognition as...
- 11From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedVaccines may help reduce the growing incidence of fungal infections in immune-suppressed patients. We have found that, even in the absence of [CD4.sup.+] T-cell help, vaccine-induced [CD8.sup.+] T cells persist and...
- 12From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedTrypanosomatid protozoan parasites lack a functional heme biosynthetic pathway, so must acquire heme from the environment to survive. However, the molecular pathway responsible for heme acquisition by these organisms is...
- 13From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedFunctional studies will facilitate characterization of role and essentiality of newly available genome sequences of the human schistosomes, Schistosoma mansoni,S. japonicum and S. haematobium. To develop transgenesis as...
- 14From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedAccumulating evidence suggests an important role for Natural Killer (NK) cells in the control of HIV-1 infection. Recently, it was shown that NK cell-mediated immune pressure can result in the selection of HIV-1 escape...
- 15From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedSmall noncoding RNAs (sRNAs) play important roles in gene regulation in both prokaryotes and eukaryotes. Thus far, no sRNA has been assigned a definitive role in virulence in the major human pathogen Streptococcus...
- 16From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedThe recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals. Conflicting reports suggest that cellular glycans...
- 17From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedNorth American triple reassortant swine (TRS) influenza A viruses have caused sporadic human infections since 2005, but human-to-human transmission has not been documented. These viruses have six gene segments (PB2,...
- 18From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedThe role of the E6 oncoprotein from high-risk members of the [alpha] human papillomavirus genus in anogenital cancer has been well established. However, far less is known about the E6 protein from the [beta] human...
- 19From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedInfection with genus beta human papillomaviruses (HPV) is implicated in the development of non-melanoma skin cancer. This was first evidenced for HPV5 and 8 in patients with epidermodysplasia verruciformis (EV), a...
- 20From: PLoS Pathogens. (Vol. 8, Issue 7) Peer-ReviewedMonocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal. The mechanisms of cell death regulating T-cell numbers at...