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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 8AndIssue Number: 7AndStart Page: e1002587AndDate: 2012 Revise Search
- 1From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedWe have developed a sparse mathematical representation of speech that minimizes the number of active model neurons needed to represent typical speech sounds. The model learns several well-known acoustic features of...
- 2From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedThe rapidly increasing amount of public data in chemistry and biology provides new opportunities for large-scale data mining for drug discovery. Systematic integration of these heterogeneous sets and provision of...
- 3From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedNext-generation sequencing (NGS) technologies have matured considerably since their introduction and a focus has been placed on developing sophisticated analytical tools to deal with the amassing volumes of data....
- 4From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedComputing is ubiquitous in every domain of scientific research. Software is the means by which scientists harness the power of computers, and much scientific computing relies on software conceived and developed by other...
- 5From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedHistone chaperones facilitate assembly and disassembly of nucleosomes. Understanding the process of how histone chaperones associate and dissociate from the histones can help clarify their roles in chromosome...
- 6From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedSynthetic biology efforts have largely focused on small engineered gene networks, yet understanding how to integrate multiple synthetic modules and interface them with endogenous pathways remains a challenge. Here we...
- 7From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedAfter extra-cellular stimulation of G-Protein Coupled Receptors (GPCRs), GDP/GTP exchange appears as the key, rate limiting step of the intracellular activation cycle of heterotrimeric G-proteins. Despite the...
- 8From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedIdentifying the factors that determine microbial growth rate under various environmental and genetic conditions is a major challenge of systems biology. While current genome-scale metabolic modeling approaches enable us...
- 9From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedMost utility theories of choice assume that the introduction of an irrelevant option (called the decoy) to a choice set does not change the preference between existing options. On the contrary, a wealth of behavioral...
- 10From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedNeurons in the insect antennal lobe represent odors as spatiotemporal patterns of activity that unfold over multiple time scales. As these patterns unspool they decrease the overlap between odor representations and...
- 11From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedWe studied the formation of trail patterns by Argentine ants exploring an empty arena. Using a novel imaging and analysis technique we estimated pheromone concentrations at all spatial positions in the experimental...
- 12From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedSpike-timing-dependent plasticity (STDP) has been observed in many brain areas such as sensory cortices, where it is hypothesized to structure synaptic connections between neurons. Previous studies have demonstrated how...
- 13From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedCerebral autoregulation (CA) is an important vascular control mechanism responsible for relatively stable cerebral blood flow despite changes of systemic blood pressure (BP). Impaired CA may leave brain tissue...
- 14From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedHigh coverage whole genome sequencing provides near complete information about genetic variation. However, other technologies can be more efficient in some settings by (a) reducing redundant coverage within samples and...
- 15From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedWith the recent success of genome-wide association studies (GWAS), a wealth of association data has been accomplished for more than 200 complex diseases/traits, proposing a strong demand for data integration and...
- 16From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedGlioblastoma multiforme (GBM) is the most common and lethal brain tumor in humans. Recent studies revealed that patterns of microRNA (miRNA) expression in GBM tissue samples are different from those in normal brain...
- 17From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedA promising strategy for drug abuse treatment is to accelerate the drug metabolism by administration of a drug-metabolizing enzyme. The question is how effectively an enzyme can actually prevent the drug from entering...
- 18From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedIt is commonly accepted that the Inferior Olive (IO) provides a timing signal to the cerebellum. Stable subthreshold oscillations in the IO can facilitate accurate timing by phase-locking spikes to the peaks of the...
- 19From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedWe have developed software for fully automated tracking of vibrissae (whiskers) in high-speed videos (>500 Hz) of head- fixed, behaving rodents trimmed to a single row of whiskers. Performance was assessed against a...
- 20From: PLoS Computational Biology. (Vol. 8, Issue 7) Peer-ReviewedThe healthy microbiota show remarkable variability within and among individuals. In addition to external exposures, ecological relationships (both oppositional and symbiotic) between microbial inhabitants are important...