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Academic Journals
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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 8AndIssue Number: 6AndStart Page: e1002699AndDate: 2012 Revise Search
- 1From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedMutations in the human Zip4 gene cause acrodermatitis enteropathica, a rare, pseudo-dominant, lethal genetic disorder. We created a tamoxifen-inducible, enterocyte-specific knockout of this gene in mice which mimics...
- 2From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedMicroRNAs (miRNAs) play important roles in normal cellular differentiation and oncogenesis. microRNA93 (mir-93), a member of the mir106b-25 cluster, located in intron 13 of the MCM7 gene, although frequently...
- 3From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedRNA turnover plays an important role in both virulence and adaptation to stress in the Gram-positive human pathogen Staphylococcus aureus. However, the molecular players and mechanisms involved in these processes are...
- 4From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedMOF is the major histone H4 lysine 16-specific (H4K16) acetyltransferase in mammals and Drosophila. In flies, it is involved in the regulation of X-chromosomal and autosomal genes as part of the MSL and the NSL...
- 5From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedInherited ataxias are characterized by degeneration of the cerebellar structures, which results in progressive motor incoordination. Hereditary ataxias occur in many species, including humans and dogs. Several mutations...
- 6From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedThe ability of bats and toothed whales to echolocate is a remarkable case of convergent evolution. Previous genetic studies have documented parallel evolution of nucleotide sequences in Prestin and KCNQ4, both of which...
- 7From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedEvolutionary forces that shape regulatory networks remain poorly understood. In mammals, the Rb pathway is a classic example of species-specific gene regulation, as a germline mutation in one Rb allele promotes...
- 8From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedThe pancreaticobiliary ductal system connects the liver and pancreas to the intestine. It is composed of the hepatopancreatic ductal (HPD) system as well as the intrahepatic biliary ducts and the intrapancreatic ducts....
- 9From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedGene duplication is a powerful driver of evolution. Newly duplicated genes acquire new roles that are relevant to fitness, or they will be lost over time. A potential path to functional relevance is mutation of the...
- 10From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedIt is widely documented that hybridisation occurs between many closely related species, but the importance of introgression in adaptive evolution remains unclear, especially in animals. Here, we have examined the role...
- 11From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedFor a quantitative understanding of the process of adaptation, we need to understand its "raw material," that is, the frequency and fitness effects of beneficial mutations. At present, most empirical evidence suggests...
- 12From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedPlants under pathogen attack produce high levels of ethylene, which plays important roles in plant immunity. Previously, we reported the involvement of ACS2 and ACS6, two Type I ACS isoforms, in Botrytis c/nerea-induced...
- 13From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedWe have taken an engineering approach to extending the lifespan of Caenorhabditis elegans. Aging stands out as a Complex trait, because events that occur in old animals are not under strong natural selection. As a...
- 14From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedEssential genes code for fundamental cellular functions required for the viability of an organism. For this reason, essential genes are often highly conserved across organisms. However, this is not always the case:...
- 15From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedChanges in gene expression are commonly observed during evolution. However, the phenotypic consequences of expression divergence are frequently unknown and difficult to measure. Transcriptional regulators provide a...
- 16From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedTranslesion synthesis (TLS) polymerases are specialized DNA polymerases capable of inserting nucleotides opposite DNA lesions that escape removal by dedicated DNA repair pathways. TLS polymerases allow cells to complete...
- 17From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedThe centromere is a functional chromosome domain that is essential for faithful chromosome segregation during cell division and that can be reliably identified by the presence of the centromere-specific histone H3...
- 18From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedZinc is an essential nutrient because it is a required cofactor for many enzymes and transcription factors. To discover genes and processes in yeast that are required for growth when zinc is limiting, we used...
- 19From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedThe long noncoding telomeric repeat containing RNA (TERRA) is expressed at chromosome ends. TERRA upregulation upon experimental manipulation or in ICF (immunodeficiency, centromeric instability, facial anomalies)...
- 20From: PLoS Genetics. (Vol. 8, Issue 6) Peer-ReviewedRose-comb, a classical monogenic trait of chickens, is characterized by a drastically altered comb morphology compared to the single-combed wild-type. Here we show that Rose-comb is caused by a 7.4 Mb inversion on...