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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 8AndIssue Number: 6AndStart Page: e1002568AndDate: 2012 Revise Search
- 1From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedThe small GTPase Rac is known to be an important regulator of cell polarization, cytoskeletal reorganization, and motility of mammalian cells. In recent microfluidic experiments, HeLa cells endowed with appropriate...
- 2From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedCell function manifests through intricately controlled dynamic processes that both interact amongst each other--in a network--and also respond to external signals, e.g., transcription factors, etc. Recently,...
- 3From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedProtein promiscuity is of considerable interest due its role in adaptive metabolic plasticity, its fundamental connection with molecular evolution and also because of its biotechnological applications. Current views on...
- 4From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedThe segmentation of the vertebrate body is laid down during early embryogenesis. The formation of signaling gradients, the periodic expression of genes of the Notch-, Fgf- and Wnt-pathways and their interplay in the...
- 5From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedNeurons communicate primarily with spikes, but most theories of neural computation are based on firing rates. Yet, many experimental observations suggest that the temporal coordination of spikes plays a role in sensory...
- 6From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedMitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer. Accumulation of...
- 7From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedBecause of the parallels found with human language production and acquisition, birdsong is an ideal animal model to study general mechanisms underlying complex, learned motor behavior. The rich and diverse vocalizations...
- 8From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedThe Mediator is a highly conserved, large multiprotein complex that is involved essentially in the regulation of eukaryotic mRNA transcription. It acts as a general transcription factor by integrating regulatory signals...
- 9From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedWe introduce a theory of sequential causal inference in which learners in a chain estimate a structural model from their upstream "teacher" and then pass samples from the model to their downstream "student". It extends...
- 10From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedVariable numbers of tandem repeats (VNTR) typing is widely used for studying the bacterial cause of tuberculosis. Knowledge of the rate of mutation of VNTR loci facilitates the study of the evolution and epidemiology of...
- 11From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedPhenotypic differences of genetically identical cells under the same environmental conditions have been attributed to the inherent stochasticity of biochemical processes. Various mechanisms have been suggested,...
- 12From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedInfluenza virus infection remains a public health problem worldwide. The mechanisms underlying viral control during an uncomplicated influenza virus infection are not fully understood. Here, we developed a mathematical...
- 13From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedContractile function of striated muscle cells depends crucially on the almost crystalline order of actin and myosin filaments in myofibrils, but the physical mechanisms that lead to myofibril assembly remains...
- 14From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedMicrobial communities carry out the majority of the biochemical activity on the planet, and they play integral roles in processes including metabolism and immune homeostasis in the human microbiome. Shotgun sequencing...
- 15From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedThe brain tumour glioblastoma is characterised by diffuse and infiltrative growth into surrounding brain tissue. At the macroscopic level, the progression speed of a glioblastoma tumour is determined by two key factors:...
- 16From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedEvaluating the importance of higher-order correlations of neural spike counts has been notoriously hard. A large number of samples are typically required in order to estimate higher-order correlations and resulting...
- 17From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedCombinatorial gene perturbations provide rich information for a systematic exploration of genetic interactions. Despite successful applications to bacteria and yeast, the scalability of this approach remains a major...
- 18From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedUnderstanding how populations of neurons encode sensory information is a major goal of systems neuroscience. Attempts to answer this question have focused on responses measured over several hundred milliseconds, a...
- 19From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedPhylogenies of highly genetically variable viruses such as HIV-1 are potentially informative of epidemiological dynamics. Several studies have demonstrated the presence of clusters of highly related HIV-1 sequences,...
- 20From: PLoS Computational Biology. (Vol. 8, Issue 6) Peer-ReviewedThe pro-apoptotic proteins Bax and Bak are essential for executing programmed cell death (apoptosis), yet the mechanism of their activation is not properly understood at the structural level. For the first time in cell...