Showing Results for
- Academic Journals (62)
Search Results
- 62
Academic Journals
- 62
- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 8AndIssue Number: 5AndStart Page: e1002724AndDate: 2012 Revise Search
- 1From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedPericardial fat is a localized fat depot associated with coronary artery calcium and myocardial infarction. We hypothesized that genetic loci would be associated with pericardial fat independent of other body fat...
- 2From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedUnderstanding the genetic pathways that regulate how pathogenic fungi respond to their environment is paramount to developing effective mitigation strategies against disease. Carbon catabolite repression (CCR) is a...
- 3From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedCommon diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We hypothesized that the genetic...
- 4From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedEukaryotic transcription factors are grouped into families and, due to their similar DNA binding domains, often have the potential to bind to the same genomic regions. This can lead to redundancy at the level of DNA...
- 5From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedThe homeotic genes in Drosophila melanogaster are aligned on the chromosome in athe order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This...
- 6From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedRegulatory networks allow organisms to match adaptive behavior to the complex and dynamic contingencies of their native habitats. Upon a sudden transition to a novel environment, the mismatch between the native behavior...
- 7From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedGenome reduction has been observed in many bacterial lineages that have adapted to specialized environments. The extreme genome degradation seen for obligate pathogens and symbionts appears to be dominated by genetic...
- 8From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedThe functional contribution of CNV to human biology and disease pathophysiology has undergone limited exploration. Recent observations in humans indicate a tentative link between CNV and weight regulation. Smith-Magenis...
- 9From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedHirschsprung disease (HSCR) is a congenital disorder characterized by aganglionosis of the distal intestine. To assess the contribution of copy number variants (CNVs) to HSCR, we analysed the data generated from our...
- 10From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedSpermatogenesis is a complex process reliant upon interactions between germ cells (GC) and supporting somatic cells. Testicular Sertoli cells (SC) support GCs during maturation through physical attachment, the provision...
- 11From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedThe centromeric regions of all Saccharomyces cerevisiae chromosomes are found in early replicating domains, a property conserved among centromeres in fungi and some higher eukaryotes. Surprisingly, little is known about...
- 12From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedSexual dimorphism in body weight, fat distribution, and metabolic disease has been attributed largely to differential effects of male and female gonadal hormones. Here, we report that the number of X chromosomes within...
- 13From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedIntraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy. The genetic factors which determine IOP are largely unknown. We performed...
- 14From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedThe epithelial-mesenchymal transition (EMT) is an embryonic transdifferentiation process consisting of conversion of polarized epithelial cells to motile mesenchymal ones. EMT-inducing transcription factors are...
- 15From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedIn both humans and Drosophila melanogaster, UDP-galactose 4'-epimerase (GALE) catalyzes two distinct reactions, interconverting UDP-galactose (UDP-gal) and UDP-glucose (UDP-glc) in the final step of the Leloir pathway...
- 16From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedTranslational repression is often accompanied by mRNA degradation. In contrast, many mRNAs in germ cells and neurons are "stored" in the cytoplasm in a repressed but stable form. Unlike repression, the stabilization of...
- 17From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedIt has been suggested that imprinted genes are important in the regulation of sleep. However, the fundamental question of whether genomic imprinting has a role in sleep has remained elusive up to now. In this work we...
- 18From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedThe stomatal pores are located on the plant leaf epidermis and regulate C[O.sub.2] uptake for photosynthesis and the loss of water by transpiration. Their stomatal aperture therefore affects photosynthesis, water use...
- 19From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedBody fat distribution, particularly centralized obesity, is associated with metabolic risk above and beyond total adiposity. We performed genome-wide association of abdominal adipose depots quantified using computed...
- 20From: PLoS Genetics. (Vol. 8, Issue 5) Peer-ReviewedIncreasing evidence suggests that chromatin modifications have important roles in modulating constitutive or alternative splicing. Here we demonstrate that the PWWP domain of the chromatin-associated protein Psip1/Ledgf...