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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 8AndIssue Number: 5AndStart Page: e1002690AndDate: 2012 Revise Search
- 1From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedTuberculosis, caused by Mycobacterium tuberculosis infection, is a major cause of morbidity and mortality in the world today. M. tuberculosis hijacks the phagosome-lysosome trafficking pathway to escape clearance from...
- 2From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedHost factors play crucial roles in the replication of plus-strand RNA viruses. In this report, a heat shock protein 90 homologue of Nicotiana benthamiana, NbHsp90, was identified in association with partially purified...
- 3From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedNoroviruses are the principal cause of epidemic gastroenteritis worldwide with GII.4 strains accounting for 80% of infections. The major capsid protein of GII.4 strains is evolving rapidly, resulting in new epidemic...
- 4From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedThe evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and...
- 5From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedMost pathogens gain access to the host through surfaces of the body that are exposed to the surrounding environment and rife with resident microorganisms, termed microbiota. Microbiota play an integral role in...
- 6From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-Reviewed
The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition
Innate immunity recognizes bacterial molecules bearing pathogen-associated molecular patterns to launch inflammatory responses leading to the activation of adaptive immunity. However, the lipopolysaccharide (LPS) of the... - 7From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedSpecific intestinal microbiota has been shown to induce [Foxp3.sup.+] regulatory T cell development. However, it remains unclear how development of another regulatory T cell subset, Tr1 cells, is regulated in the...
- 8From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedRespiratory syncytial virus (RSV) protein M2-1 functions as an essential transcriptional cofactor of the viral RNA- dependent RNA polymerase (RdRp) complex by increasing polymerase processivity. M2-1 is a modular RNA...
- 9From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedKaposi's sarcoma-associated herpesvirus (KSHV) is the cause of Kaposi's sarcoma and body cavity lymphomas. KSHV lytic infection produces PAN RNA, a highly abundant noncoding polyadenylated transcript that is retained in...
- 10From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedThe coronavirus E protein is a small membrane protein with a single predicted hydrophobic domain (HD), and has a poorly defined role in infection. The E protein is thought to promote virion assembly, which occurs in the...
- 11From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedLow vitamin D levels in human immunodeficiency virus type-1 (HIV) infected persons are associated with more rapid disease progression and increased risk for Mycobacterium tuberculosis infection. We have previously shown...
- 12From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedInterferon protects mice from vesicular stomatitis virus (VSV) infection and pathogenesis; however, it is not known which of the numerous interferon-stimulated genes (ISG) mediate the antiviral effect. A prominent...
- 13From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedInfluenza viruses are characterized by an ability to cross species boundaries and evade host immunity, sometimes with devastating consequences. The 2009 pandemic of H1N1 influenza A virus highlights the importance of...
- 14From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedMHC class Ia-restricted [CD8.sup.+] T cells are important mediators of the adaptive immune response against infections caused by intracellular microorganisms. Whereas antigen-specific effector [CD8.sup.+] T cells can...
- 15From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedRotavirus is a major cause of diarrhea worldwide and exhibits a pronounced small intestinal epithelial cell (IEC) tropism. Both human infants and neonatal mice are highly susceptible, whereas adult individuals remain...
- 16From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedRecent studies have greatly increased understanding of how the immune system of insects responds to infection, whereas much less is known about how pathogens subvert immune defenses. Key regulators of the insect immune...
- 17From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedHepatitis C virus (HCV) is an important cause of chronic liver disease. Several highly diverse HCV genotypes exist with potential key functional differences. The HCV NS5A protein was associated with response to...
- 18From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedAlthough evolution is a multifactorial process, theory posits that the speed of molecular evolution should be directly determined by the rate at which spontaneous mutations appear. To what extent these two biochemical...
- 19From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedImmunological checkpoints, such as the inhibitory CD200 receptor (CD200R), play a dual role in balancing the immune system during microbial infection. On the one hand these inhibitory signals prevent excessive immune...
- 20From: PLoS Pathogens. (Vol. 8, Issue 5) Peer-ReviewedParvoviruses exploit transferrin receptor type-1 (TfR) for cellular entry in carnivores, and specific interactions are key to control of host range. We show that several key mutations acquired by TfR during the...