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- 1From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedThe innate immune system, acting as the first line of host defense, senses and adapts to foreign challenges through complex intracellular and intercellular signaling networks. Endotoxin tolerance and priming elicited by...
- 2From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedMany morphogenetic processes involve mechanical rearrangements of epithelial tissues that are driven by precisely regulated cytoskeletal forces and cell adhesion. The mechanical state of the cell and intercellular...
- 3From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedThere are many well-known examples of proteins with low sequence similarity, adopting the same structural fold. This aspect of sequence-structure relationship has been extensively studied both experimentally and...
- 4From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedFor processing and segmenting visual scenes, the brain is required to combine a multitude of features and sensory channels. It is neither known if these complex tasks involve optimal integration of information, nor...
- 5From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedMuscle coordination studies repeatedly show low-dimensionality of muscle activations for a wide variety of motor tasks. The basis vectors of this low-dimensional subspace, termed muscle synergies, are hypothesized to...
- 6From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedThe role of the basement membrane is vital in maintaining the integrity and structure of an epithelial layer, acting as both a mechanical support and forming the physical interface between epithelial cells and the...
- 7From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedAlthough general anesthetics are known to modulate the activity of ligand-gated ion channels in the Cys-loop superfamily, there is at present neither consensus on the underlying mechanisms, nor predictive models of this...
- 8From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedWe survey low cost high-throughput virtual screening (HTVS) computer programs for instructors who wish to demonstrate molecular docking in their courses. Since HTVS programs are a useful adjunct to the time consuming...
- 9From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedFunctional brain network studies using the Blood Oxygen-Level Dependent (BOLD) signal from functional Magnetic Resonance Imaging (fMRI) are becoming increasingly prevalent in research on the neural basis of human...
- 10From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedWe have created a statistically grounded tool for determining the correlation of genomewide data with other datasets or known biological features, intended to guide biological exploration of high-dimensional datasets,...
- 11From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedAnimals can exhibit complex movement patterns that may be the result of interactions with their environment or may be directly the mechanism by which their behaviour is governed. In order to understand the drivers of...
- 12From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedPain caused by nerve injury (i.e. neuropathic pain) is associated with development of neuronal hyperexcitability at several points along the pain pathway. Within primary afferents, numerous injury-induced changes have...
- 13From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedWhat factors determine a protein's rate of evolution are actively debated. Especially unclear is the relative role of intrinsic factors of present-day proteins versus historical factors such as protein age. Here we...
- 14From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedPredicting the clinical outcome of cancer patients based on the expression of marker genes in their tumors has received increasing interest in the past decade. Accurate predictors of outcome and response to therapy...
- 15From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedNeurons adjust their intrinsic excitability when experiencing a persistent change in synaptic drive. This process can prevent neural activity from moving into either a quiescent state or a saturated state in the face of...
- 16From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedMosquito host-seeking behavior and heterogeneity in host distribution are important factors in predicting the transmission dynamics of mosquito-borne infections such as dengue fever, malaria, chikungunya, and West Nile...
- 17From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedThe cell division cycle and the circadian clock represent two major cellular rhythms. These two periodic processes are coupled in multiple ways, given that several molecular components of the cell cycle network are...
- 18From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedGene Ontology (GO) has established itself as the undisputed standard for protein function annotation. Most annotations are inferred electronically, i.e. without individual curator supervision, but they are widely...
- 19From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedA major challenge in computational neurobiology is to understand how populations of noisy, broadly-tuned neurons produce accurate goal-directed actions such as saccades. Saccades are high-velocity eye movements that...
- 20From: PLoS Computational Biology. (Vol. 8, Issue 5) Peer-ReviewedIn many cell types, release of calcium ions is controlled by inositol 1,4,5-trisphosphate ([IP.sub.3]) receptor channels. Elevations in [Ca.sup.2+] concentration after intracellular release through [IP.sub.3] receptors...