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- 1From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedA compound for staining amyloid aggregates is found to slow aging and increase lifespan in Caenorhabditis elegans. Thioflavin T, a widely used dye for selectively staining amyloid aggregates, both in vitro and in...
- 2From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedWe report a simple method, using p53 suppression and nontransforming L-Myc, to generate human induced pluripotent stem cells (iPSCs) with episomal plasmid vectors. We generated human iPSCs from multiple donors,...
- 3From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedThe cell-attached patch clamp configuration is useful for investigating the functional properties of voltage-activated ion channels without substantially disturbing the rest of the cell. Williams and Wozny carefully...
- 4From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedIt has been a little more than a decade since Thomson and colleagues first described the successful isolation and propagation of human embryonic stem cells (ESCs) (1). Much has changed since then. Pluripotent cell lines...
- 5From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedOur goal when writing research papers is to convey information as clearly as possible. In past columns I have suggested several graphic design techniques to improve the clarity of figures. In addition to refining data...
- 6From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedSelected reaction monitoring (SRM) is a targeted mass spectrometric method that is increasingly used in proteomics for the detection and quantification of sets of preselected proteins at high sensitivity,...
- 7From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedA recent study turns the creation of conditional short hairpin RNA transgenic mice into a rapid, flexible and scalable process. Manipulating gene expression in the mouse, either by overexpressing exogenous genes or...
- 8From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedA key challenge when imaging living cells is how to noninvasively extract the most spatiotemporal information possible. Unlike popular wide-field and confocal methods, plane-illumination microscopy limits excitation to...
- 9From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedPhymmBL combines two components: (i) composition-directed taxonomic predictions from Phymm and (ii) basic local alignment search tool (BLAST)-based homology results (2). PhymmBL combines these to label each input...
- 10From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedThe application of infrared spectroscopy technologies has gained increasing recognition in recent years as an adjunct support to more traditional methodologies, especially in cell biology (1-3). A report from...
- 11From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedIn proteomics applications, especially for de novo sequencing and identifying protein modifications, peptides can be efficiently fragmented by tandem mass spectrometry via high-energy collision-induced dissociation...
- 12From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedHigh-coverage sequencing of RNA interference targets gives insight into parasite phenotypes. If you live in sub-Saharan Africa, the bite of a fly can have life-threatening consequences. Trypanosomes, transmitted to...
- 13From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedExisting transgenic RNAi resources in Drosophila melanogaster based on long double-stranded hairpin RNAs are powerful tools for functional studies, but they are ineffective in gene knockdown during oogenesis, an...
- 14From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedRohit Bhargava expected that 12 beams from a synchrotron would boost the quality of his imaging data, but he still was not prepared for what he saw. Bhargava, a bioengineer at the University of Illinois at...
- 15From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedMaps of chromatin-state dynamics identify regulatory elements across nine human cell types. How genes are regulated can be just as important as the proteins they encode. Regulatory elements in the genome are much...
- 16From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedWe often hear the adage 'he who dies with the most [toys], wins', but in recent times the opposite saying 'he who needs the least, wins' has become popular. These sayings summarize two very different approaches to life...
- 17From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedResearchers have taken first steps toward functional connectomics. By combining large-scale serial electron microscopy and functional imaging data, the structure of neural networks can be related to their function....
- 18From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedAs it strives to maximize profits, industry devotes considerable effort to improving the efficiency of its processes. Henry Ford's assembly line revolutionized automobile manufacturing, and subsequent developments in...
- 19From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedIn the late 1990s, before the publication of the human genome, John Rinn, then at Yale University, was hunting for protein genes on chromosome 22 with his graduate student adviser Michael Snyder. The only genes they...
- 20From: Nature Methods. (Vol. 8, Issue 5) Peer-ReviewedTwo-photon excitation of fluorescent proteins is an attractive approach for imaging living systems. Today researchers are eager to know which proteins are the brightest and what the best excitation wavelengths are. Here...