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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 8AndIssue Number: 4AndStart Page: e1002637AndDate: 2012 Revise Search
- 1From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedExplaining the contribution of host and pathogen factors in driving infection dynamics is a major ambition in parasitology. There is increasing recognition that analyses based on single summary measures of an infection...
- 2From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedBiomphalaria glabrata snails that display either resistant or susceptible phenotypes to the parasitic trematode, Schistosoma mansoni provide an invaluable resource towards elucidating the molecular basis of the...
- 3From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedAmrZ, a member of the Ribbon-Helix-Helix family of DNA binding proteins, functions as both a transcriptional activator and repressor of multiple genes encoding Pseudomonas aeruginosa virulence factors. The expression of...
- 4From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedIn Chagas disease, [CD8.sup.+] T-cells are critical for the control of Trypanosoma cruzi during acute infection. Conversely, [CD8.sup.+] T-cell accumulation in the myocardium during chronic infection may cause tissue...
- 5From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedInfluenza viruses continue to pose a major public health threat worldwide and options for antiviral therapy are limited by the emergence of drug-resistant virus strains. The antiviral cytokine, interferon (IFN) is an...
- 6From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedVirulent biofilms are responsible for a range of infections, including oral diseases. All biofilms harbor a microbial-derived extracellular-matrix. The exopolysaccharides (EPS) formed on tooth-pellicle and bacterial...
- 7From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedNlrp1b is a NOD-like receptor that detects the catalytic activity of anthrax lethal toxin and subsequently co- oligomerizes into a pro-caspase-1 activation platform known as an inflammasome. Nlrp1b has two domains that...
- 8From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedPhytopathogens secrete effector proteins to manipulate their hosts for effective colonization. Hemibiotrophic fungi must maintain host viability during initial biotrophic growth and elicit host death for subsequent...
- 9From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedThe transferrin receptor of bloodstream form Trypanosoma brucei is a heterodimer encoded by expression site associated genes 6 and 7. This low-abundance glycoprotein with a single glycosylphosphatidylinositol membrane...
- 10From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedCandida albicans is an important opportunistic fungal pathogen of immunocompromised individuals. One critical virulence attribute is its morphogenetic plasticity. Hyphal development requires two temporally linked...
- 11From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedIntroduction The term "prion" was originally coined by Prusiner to explain the unusual infectious agent in transmissible spongiform encephalopathies (TSEs, also known as prion disease) [1]. Now the term has expanded...
- 12From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedSalmonella is a principal health concern because of its endemic prevalence in food and water supplies, the rise in incidence of multi-drug resistant strains, and the emergence of new strains associated with increased...
- 13From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedRNA modification plays an important role in modulating host-pathogen interaction. Flavivirus NS5 protein encodes N-7 and 2'-O methyltransferase activities that are required for the formation of 5' type I cap...
- 14From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedMembers of the IL-17 cytokine family play an important role in protection against pathogens through the induction of different effector mechanisms. We determined that IL-17A, IL-17E and IL-17F are produced during the...
- 15From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedPathogens offer many of the most fascinating and well-studied examples of evolution because their speed of adaptation allows observation of evolutionary change within human lifetimes. The rapid evolution observed in...
- 16From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedT cell cross-reactivity between different strains of the same virus, between different members of the same virus group, and even between unrelated viruses is a common occurrence. We questioned here how an intervening...
- 17From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedBordetella adenylate cyclase toxin-hemolysin (CyaA) penetrates the cytoplasmic membrane of phagocytes and employs two distinct conformers to exert its multiple activities. One conformer forms cation-selective pores that...
- 18From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedMany plants release airborne volatile compounds in response to wounding due to pathogenic assault. These compounds serve as plant defenses and are involved in plant signaling. Here, we study the effects of pectin...
- 19From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedThe majority of broadly neutralizing antibodies to hepatitis C virus (HCV) are against conformational epitopes on the E2 glycoprotein. Many of them recognize overlapping epitopes in a cluster, designated as antigenic...
- 20From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedTrehalose 6,6'-dimycolate (TDM), a cord factor of Mycobacterium tuberculosis (Mtb), is an important regulator of immune responses during Mtb infections. Macrophages recognize TDM through the Mincle receptor and initiate...