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- 1From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedExplaining the contribution of host and pathogen factors in driving infection dynamics is a major ambition in parasitology. There is increasing recognition that analyses based on single summary measures of an infection...
- 2From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedBiomphalaria glabrata snails that display either resistant or susceptible phenotypes to the parasitic trematode, Schistosoma mansoni provide an invaluable resource towards elucidating the molecular basis of the...
- 3From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedAmrZ, a member of the Ribbon-Helix-Helix family of DNA binding proteins, functions as both a transcriptional activator and repressor of multiple genes encoding Pseudomonas aeruginosa virulence factors. The expression of...
- 4From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedIn Chagas disease, [CD8.sup.+] T-cells are critical for the control of Trypanosoma cruzi during acute infection. Conversely, [CD8.sup.+] T-cell accumulation in the myocardium during chronic infection may cause tissue...
- 5From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedInfluenza viruses continue to pose a major public health threat worldwide and options for antiviral therapy are limited by the emergence of drug-resistant virus strains. The antiviral cytokine, interferon (IFN) is an...
- 6From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedVirulent biofilms are responsible for a range of infections, including oral diseases. All biofilms harbor a microbial-derived extracellular-matrix. The exopolysaccharides (EPS) formed on tooth-pellicle and bacterial...
- 7From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedNlrp1b is a NOD-like receptor that detects the catalytic activity of anthrax lethal toxin and subsequently co- oligomerizes into a pro-caspase-1 activation platform known as an inflammasome. Nlrp1b has two domains that...
- 8From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedPhytopathogens secrete effector proteins to manipulate their hosts for effective colonization. Hemibiotrophic fungi must maintain host viability during initial biotrophic growth and elicit host death for subsequent...
- 9From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedThe transferrin receptor of bloodstream form Trypanosoma brucei is a heterodimer encoded by expression site associated genes 6 and 7. This low-abundance glycoprotein with a single glycosylphosphatidylinositol membrane...
- 10From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedCandida albicans is an important opportunistic fungal pathogen of immunocompromised individuals. One critical virulence attribute is its morphogenetic plasticity. Hyphal development requires two temporally linked...
- 11From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedRNA modification plays an important role in modulating host-pathogen interaction. Flavivirus NS5 protein encodes N-7 and 2'-O methyltransferase activities that are required for the formation of 5' type I cap...
- 12From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedMembers of the IL-17 cytokine family play an important role in protection against pathogens through the induction of different effector mechanisms. We determined that IL-17A, IL-17E and IL-17F are produced during the...
- 13From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedIntroduction The term "prion" was originally coined by Prusiner to explain the unusual infectious agent in transmissible spongiform encephalopathies (TSEs, also known as prion disease) [1]. Now the term has expanded...
- 14From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedSalmonella is a principal health concern because of its endemic prevalence in food and water supplies, the rise in incidence of multi-drug resistant strains, and the emergence of new strains associated with increased...
- 15From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedTrehalose 6,6'-dimycolate (TDM), a cord factor of Mycobacterium tuberculosis (Mtb), is an important regulator of immune responses during Mtb infections. Macrophages recognize TDM through the Mincle receptor and initiate...
- 16From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedThe cell intrinsic innate immune responses provide a first line of defense against viral infection, and often function by targeting cellular pathways usurped by the virus during infection. In particular, many viruses...
- 17From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedUncovering how natural selection and genetic drift shape the evolutionary dynamics of virus populations within their hosts can pave the way to a better understanding of virus emergence. Mathematical models already play...
- 18From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedFlavivirus envelope protein (E) mediates membrane fusion and viral entry from endosomes. A low-pH induced, dimer-to- trimer rearrangement and reconfiguration of the membrane-proximal "stem" of the E ectodomain draw...
- 19From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedBK polyomavirus (BKV or BKPyV) associated nephropathy affects up to 10% of kidney transplant recipients (KTRs). BKV isolates are categorized into four genotypes. It is currently unclear whether the four genotypes are...
- 20From: PLoS Pathogens. (Vol. 8, Issue 4) Peer-ReviewedAlthough mast cells are best known for their role in mediating allergic diseases, recent studies have highlighted the important role that these cells play in the protection against infection with a variety of organisms....