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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 8AndIssue Number: 3AndStart Page: e1002547AndDate: 2012 Revise Search
- 1From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedElastase-mediated cleavage of cyclin E generates low molecular weight cyclin E (LMW-E) isoforms exhibiting enhanced CDK2-associated kinase activity and resistance to inhibition by CDK inhibitors p21 and p27....
- 2From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedPlanarian flatworms are able to both regenerate their whole bodies and continuously adapt their size to nutrient status. Tight control of stem cell proliferation and differentiation during these processes is the key...
- 3From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedSeveral genetic variants associated with platelet count and mean platelet volume (MPV) were recently reported in people of European ancestry. In this meta-analysis of 7 genome-wide association studies (GWAS) enrolling...
- 4From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedThe Dobzhansky and Muller (D-M) model explains the evolution of hybrid incompatibility (HI) through the interaction between lineage-specific derived alleles at two or more loci. In agreement with the expectation that HI...
- 5From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedThe divergence of distinct cell populations from multipotent progenitors is poorly understood, particularly in vivo. The gonad is an ideal place to study this process, because it originates as a bipotential primordium...
- 6From: PLoS Genetics. (Vol. 8, Issue 3) Peer-Reviewedlin-28 is a conserved regulator of cell fate succession in animals. In Caenorhabditis elegans, it is a component of the heterochronic gene pathway that governs larval developmental timing, while its vertebrate homologs...
- 7From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedTo investigate the regulation of seed metabolism and to estimate the degree of metabolic natural variability, metabolite profiling and network analysis were applied to a collection of 76 different homozygous tomato...
- 8From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedMeta-analysis is an increasingly popular tool for combining multiple genome-wide association studies in a single analysis to identify associations with small effect sizes. The effect sizes between studies in a...
- 9From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedNephrolithiasis is a common nephrologic disorder with complex etiology. To identify the genetic factor(s) for nephrolithiasis, we conducted a three-stage genome-wide association study (GWAS) using a total of 5,892...
- 10From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedApoptosis is essential to prevent oncogenic transformation by triggering self-destruction of harmful cells, including those unable to differentiate. However, the mechanisms linking impaired cell differentiation and...
- 11From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedNeurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous knockout (KO) mice, Nbea deficiency causes...
- 12From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedMost genes along the male single X chromosome in Drosophila are hypertranscribed about two-fold relative to each of the two female X chromosomes. This is accomplished by the MSL (male-specific lethal) complex that...
- 13From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedIn contrast to existing estimates of approximately 200 murine imprinted genes, recent work based on transcriptome sequencing uncovered parent-of-origin allelic effects at more than 1,300 loci in the developing brain and...
- 14From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedMicroRNA (miRNA)-mediated gene regulation is of critical functional importance in animals and is thought to be largely constrained during evolution. However, little is known regarding evolutionary changes of the miRNA...
- 15From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedIron plays an essential role in many biological processes, but also catalyzes the formation of reactive oxygen species (ROS), which can cause molecular damage. Iron homeostasis is therefore a critical determinant of...
- 16From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedIn order to grow, immature insects must periodically synthesize a new cuticle and shed the old one (a process of molting and ecdysis) until they have reached a stage permitting metamorphosis to the reproductive adult....
- 17From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedPolycomb repressive complex 2 (PRC2) trimethylates lysine 27 of histone H3 (H3K27me3) to regulate gene expression during diverse biological transitions in development, embryonic stem cell (ESC) differentiation, and...
- 18From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedAneuploidy and gross chromosomal rearrangements (GCRs) can lead to genetic diseases and the development of cancer. We previously demonstrated that introduction of the repetitive retrotransposon Ty912 onto a nonessential...
- 19From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedShade avoidance is an ecologically and molecularly well-understood set of plant developmental responses that occur when the ratio of red to far-red light (R:FR) is reduced as a result of foliar shade. Here, a...
- 20From: PLoS Genetics. (Vol. 8, Issue 3) Peer-ReviewedThe molecular chaperone Hsp90 regulates the folding of diverse signal transducers in all eukaryotes, profoundly affecting cellular circuitry. In fungi, Hsp90 influences development, drug resistance, and evolution. Hsp90...