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- 1From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedThe African sex workers who seem to be 'immune' to human immunodeficiency virus (HIV) (1) have captured the imagination of HIV-AIDS researchers worldwide. The existence of such women who, in contrast to their peers, fail...
- 2From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedThe programmed cell death 1 (PD-1) surface receptor binds to two ligands, PD-L1 and PD-L2. Studies have shown that PD-1-PD-L interactions control the induction and maintenance of peripheral T cell tolerance and indicate...
- 3From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedDuring adaptive immune responses, dendritic cells activate T cells and endow them with specific homing properties. Mechanisms that 'imprint' specific tropisms, however, are not well defined. We show here that...
- 4From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedT cell receptor (TCR) signaling activates the calcium-sensitive phosphatase calcineurin, whose activity is required for IL-2 expression and other 'downstream' activation events. In Nature, Pan et al. identify carabin as...
- 5From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedThe migration of lymphocytes to regions outside lymphoid organs (extralymphoid regions), such as the skin and the intestinal tract, is controlled by the expression of homing and chemokine receptors, which respond to...
- 6From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedInbred mouse strains have heritable differences in the population sizes (total numbers) of bone marrow hematopoietic stem cells (HSCs). In Nature Genetics, Van Zant and colleagues identify a gene, Lxn, that regulates the...
- 7From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedStudies of lipid-specific T cells have identified many facets of their biology. Some features resemble those of peptide-specific T cells, whereas others are distinct and reflect the biochemical nature of recognized...
- 8From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedTo the editor: In a recent Perspective in Nature Immunology (1), Blander and Medzhitov explored the function of Toll-like receptor (TLR) signaling in controlling the maturation of phagosomes in macrophages and...
- 9From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedRegulatory T cells ([T.sub.reg] cells) express CD4 and CD25 and require both IL-2 and cell-intrinsic expression of the transcription factor Foxp3 for full development and maintenance of function. In the Journal of...
- 10From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedMucosal surfaces are continually exposed to external stimuli and are highly vulnerable portals for pathogen entry. The epithelial cells (ECs) that line mucosal surfaces are the frontline dynamic barriers that protect the...
- 11From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedPlasticity of the T cell receptor (TCR) is a hallmark of major histocompatibility complex (MHC)-restricted T cell recognition. However, it is unclear whether interactions of TCR and peptide-MHC class I (pMHCI) always...
- 12From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedThe thymus achieves two interrelated functions essential for the tasks of the adaptive immune system: the lifelong generation of new T cells, and the production of T cells expressing a T cell receptor repertoire that is...
- 13From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedThe autoimmune regulator Aire is expressed in a small proportion of medullary thymic epithelial cells (mTECs) and is crucial in the induction of central T cell tolerance. The origin and development of [Aire.sup.+] mTECS,...
- 14From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedCytotoxic T lymphocytes and natural killer cells exert their cytotoxic activity through the polarized secretion of cytotoxic granules at the immunological synapse. Rab27a and hMunc13-4 are critical effectors of the...
- 15From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedThe importance of interleukin 17 (IL-17)--producing [CD4.sup.+] T helper cells ([T.sub.H]-17 cells) in health and disease is evident from their involvement in several settings. [T.sub.H]-17 cells are linked to the...
- 16From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedNaive [CD8.sup.+] T cells can be primed in the liver, but the capacity of various intrahepatic cell types to stimulate T cells is not well understood. In Immunity, Kaufmann and colleagues show that hepatic Ito cells can...
- 17From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedEpithelial cells (ECs) transport class-switched immunoglobulin G (IgG) and IgA antibodies across mucous membranes. Whether ECs initiate class switching remains unknown. Here we found that ECs lining tonsillar crypts...
- 18From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedMast cells are key effector cells in allergic reactions. Aggregation of the receptor FccRI in mast cells triggers the influx of calcium ([Ca.sup.2+]) and the release of inflammatory mediators. Here we show that transient...
- 19From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedAnyone following the media cannot have escaped the seemingly endless reports of scientific misconduct. Two high-profile cases, with former Massachusetts Institute of Technology immunologist Luk Van Parijs and the...
- 20From: Nature Immunology. (Vol. 8, Issue 3) Peer-ReviewedT helper cells that produce interleukin 17 (IL-17) are associated with inflammation and the control of certain bacteria. We report here the essential involvement of the adaptor protein Act1 in IL-17 receptor (IL-17R)...