Showing Results for
- Academic Journals (36)
Search Results
- 36
Academic Journals
- 36
- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 8AndIssue Number: 2AndStart Page: e1002521AndDate: 2012 Revise Search
- 1From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedMeasureable rates of genome evolution are well documented in human pathogens but are less well understood in bacterial pathogens in the wild, particularly during and after host switches. Mycoplasma gallisepticum (MG) is...
- 2From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedOverexpression or mutation of [alpha]-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function. We used a whole-genome screen in...
- 3From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedAberrant DNA methylation is an important cancer hallmark, yet the dynamics of DNA methylation changes in human carcinogenesis remain largely unexplored. Moreover, the role of DNA methylation for prediction of clinical...
- 4From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedKnowledge of the mechanisms for regulating lifespan is advancing rapidly, but lifespan is a complex phenotype and new features are likely to be identified. Here we reveal a novel approach for regulating lifespan. Using...
- 5From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedAs early as 1912, Wilhelm Weinberg, the visionary human geneticist, noted that infants with achondroplasia (short-limbed dwarfism) tended to be born late in their sibship [1]. From this he made the astonishing...
- 6From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedMultiple endocrine neoplasia type 2B (MEN2B) is a highly aggressive thyroid cancer syndrome. Since almost all sporadic cases are caused by the same nucleotide substitution in the RET proto-oncogene, the calculated...
- 7From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedPhospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their...
- 8From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedThe resolution of chromosomes during anaphase is a key step in mitosis. Failure to disjoin chromatids compromises the fidelity of chromosome inheritance and generates aneuploidy and chromosome rearrangements, conditions...
- 9From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedShifts between epigenetic states of transcriptional activity are typically correlated with changes in epigenetic marks. However, exceptions to this rule suggest the existence of additional, as yet uncharacterized,...
- 10From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedAutism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders with a complex inheritance pattern. While many rare variants in synaptic proteins have been identified in patients with ASD,...
- 11From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedNon-coding transcription can trigger histone post-translational modifications forming specialized chromatin. In fission yeast, heterochromatin formation requires RNAi and the histone H3K9 methyltransferase complex CLRC,...
- 12From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedMutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 encodes a large multi-domain...
- 13From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedFor self-pollinating plants to reproduce, male and female organ development must be coordinated as flowers mature. The Arabidopsis transcription factors AUXIN RESPONSE FACTOR 6 (ARF6) and ARF8 regulate this complex...
- 14From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedWhy gene order is conserved over long evolutionary timespans remains elusive. A common interpretation is that gene order conservation might reflect the existence of functional constraints that are important for...
- 15From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedA hallmark feature of Williams-Beuren Syndrome (WBS) is a generalized arteriopathy due to elastin deficiency, presenting as stenoses of medium and large arteries and leading to hypertension and other cardiovascular...
- 16From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedRecurrent submicroscopic deletions in genes affecting key cellular pathways are a hallmark of pediatric acute lymphoblastic leukemia (ALL). To gain more insight into the mechanism underlying these deletions, we have...
- 17From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedGene conversion is the unidirectional transfer of genetic information between orthologous (allelic) or paralogous (nonallelic) genomic segments. Though a number of studies have examined nucleotide replacements, little...
- 18From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedDevil facial tumour disease (DFTD) is a fatal, transmissible malignancy that threatens the world's largest marsupial carnivore, the Tasmanian devil, with extinction. First recognised in 1996, DFTD has had a catastrophic...
- 19From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedmiR-124 is conserved in sequence and neuronal expression across the animal kingdom and is predicted to have hundreds of mRNA targets. Diverse defects in neural development and function were reported from miR-124...
- 20From: PLoS Genetics. (Vol. 8, Issue 2) Peer-ReviewedWith the expansion of offender/arrestee DNA profile databases, genetic forensic identification has become commonplace in the United States criminal justice system. Implementation of familial searching has been proposed...