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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 8AndIssue Number: 2AndStart Page: e1002464AndDate: 2012 Revise Search
- 1From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedCD8 T cell responses have three phases: expansion, contraction, and memory. Dynamic alterations in proliferation and apoptotic rates control CD8 T cell numbers at each phase, which in turn dictate the magnitude of CD8 T...
- 2From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedGammaherpesvirus cyclins have expanded biochemical features relative to mammalian cyclins, and promote infection and pathogenesis including acute lung infection, viral persistence, and reactivation from latency. To...
- 3From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedThe Epstein-Barr virus (EBV) latent-lytic switch is mediated by the BZLF1 immediate-early protein. EBV is normally latent in memory B cells, but cellular factors which promote viral latency specifically in B cells have...
- 4From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedTuberculosis (TB) and HIV co-infections place an immense burden on health care systems and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most powerful known risk factor predisposing...
- 5From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedReplication of plus-strand RNA viruses depends on recruited host factors that aid several critical steps during replication. In this paper, we show that an essential translation factor, Ded1p DEAD-box RNA helicase of...
- 6From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedSurvival within macrophages is a central feature of Mycobacterium tuberculosis pathogenesis. Despite significant advances in identifying new immunological parameters associated with mycobacterial disease, some basic...
- 7From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedHeterotrimeric G-proteins are molecular switches integral to a panoply of different physiological responses that many organisms make to environmental cues. The switch from inactive to active G[alpha][beta][gamma]...
- 8From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedMany studies have been devoted to understand the mechanisms used by pathogenic bacteria to exploit human hosts. These mechanisms are very diverse in the detail, but share commonalities whose quantification should...
- 9From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedA subset of human papillomavirus (HPV) infections is causally related to the development of human epithelial tumors and cancers. Like a number of pathogens, HPV entry into target cells is initiated by first binding to...
- 10From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedHerpes simplex virus (HSV) types 1 and 2 are highly prevalent human neurotropic pathogens that cause a variety of diseases, including lethal encephalitis. The relationship between HSV and the host immune system is one...
- 11From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedAnthelmintic drug resistance in livestock parasites is already widespread and in recent years there has been an increasing level of anthelmintic drug selection pressure applied to parasitic nematode populations in...
- 12From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedThe early host response to viral infections involves transient activation of pattern recognition receptors leading to an induction of inflammatory cytokines such as interleukin-1 [beta] (IL-1[beta]) and tumor necrosis...
- 13From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedLegionella pneumophila, the causative agent of Legionnaires' disease, invades and replicates within macrophages and protozoan cells inside a vacuole. The type IVB Icm/Dot secretion system is necessary for the...
- 14From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-Reviewed
Structural and functional insights into the pilotin-secretin complex of the type II secretion system
Gram-negative bacteria secrete virulence factors and assemble fibre structures on their cell surface using specialized secretion systems. Three of these, T2SS, T3SS and T4PS, are characterized by large outer membrane... - 15From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedStomata play an important role in plant innate immunity by limiting pathogen entry into leaves but molecular mechanisms regulating stomatal closure upon pathogen perception are not well understood. Here we show that the...
- 16From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedLaeA and VeA coordinate secondary metabolism and differentiation in response to light signals in Aspergillus spp. Their orthologs, ChLae1 and ChVel1, were identified in the maize pathogen Cochliobolus heterostrophus,...
- 17From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedCell-substrate adherence is a fundamental property of microorganisms that enables them to exist in biofilms. Our study focuses on adherence of the fungal pathogen Candida albicans to one substrate, silicone, that is...
- 18From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedHerpes simplex virus type-1 (HSV-1) establishes latency in peripheral neurons, creating a permanent source of recurrent infections. The latent genome is assembled into chromatin and lytic cycle genes are silenced....
- 19From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedReplication of plus-stranded RNA viruses is greatly affected by numerous host-coded proteins acting either as susceptibility or resistance factors. Previous genome-wide screens and global proteomics approaches with...
- 20From: PLoS Pathogens. (Vol. 8, Issue 2) Peer-ReviewedThe eukaryotic cytoskeleton is essential for structural support and intracellular transport, and is therefore a common target of animal pathogens. However, no phytopathogenic effector has yet been demonstrated to...