Showing Results for
- Academic Journals (34)
Search Results
- 34
Academic Journals
- 34
- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 8AndIssue Number: 2AndStart Page: e1002400AndDate: 2012 Revise Search
- 1From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedCritical transitions are sudden, often irreversible, changes that can occur in a large variety of complex systems; signals that warn of critical transitions are therefore highly desirable. We propose a new method for...
- 2From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedShewanella oneidensis MR-1 sequentially utilizes lactate and its waste products (pyruvate and acetate) during batch culture. To decipher MR-1 metabolism, we integrated genome-scale flux balance analysis (FBA) into a...
- 3From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedResearchers have conjectured that eye movements during visual search are selected to minimize the number of saccades. The optimal Bayesian eye movement strategy minimizing saccades does not simply direct the eye to...
- 4From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedCortisol, secreted in the adrenal cortex in response to stress, is an informative biomarker that distinguishes anxiety disorders such as major depression and post-traumatic stress disorder (PTSD) from normal subjects....
- 5From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedDetermining the functional structure of biological networks is a central goal of systems biology. One approach is to analyze gene expression data to infer a network of gene interactions on the basis of their correlated...
- 6From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedThe infection cycle of viruses creates many opportunities for the exchange of genetic material with the host. Many viruses integrate their sequences into the genome of their host for replication. These processes may...
- 7From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedHD amino acid duplex has been found in the active center of many different enzymes. The dyad plays remarkably different roles in their catalytic processes that usually involve metal coordination. An HD motif is...
- 8From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedCognitive skills undergo protracted developmental changes resulting in proficiencies that are a hallmark of human cognition. One skill that develops over time is the ability to problem solve, which in turn relies on...
- 9From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedAtrial fibrillation, a common cardiac arrhythmia, often progresses unfavourably: in patients with long-term atrial fibrillation, fibrillatory episodes are typically of increased duration and frequency of occurrence...
- 10From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedMany organs of higher organisms, such as the vascular system, lung, kidney, pancreas, liver and glands, are heavily branched structures. The branching process during lung development has been studied in great detail and...
- 11From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedIn networks of excitatory and inhibitory neurons with mutual synaptic coupling, specific drive to sub-ensembles of cells often leads to gamma-frequency (25-100 Hz) oscillations. When the number of driven cells is too...
- 12From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedRiboswitches are RNAs that modulate gene expression by ligand-induced conformational changes. However, the way in which sequence dictates alternative folding pathways of gene regulation remains unclear. In this study,...
- 13From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedDecisions about noisy stimuli require evidence integration over time. Traditionally, evidence integration and decision making are described as a one-stage process: a decision is made when evidence for the presence of a...
- 14From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedA recent paper (Nehrt et al., PLoS Comput. Biol. 7:e1002073, 2011) has proposed a metric for the "functional similarity" between two genes that uses only the Gene Ontology (GO) annotations directly derived from...
- 15From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-Reviewed"Use it and improve it, or lose it" is one of the axioms of motor therapy after stroke. There is, however, little understanding of the interactions between arm function and use in humans post-stroke. Here, we explored...
- 16From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedThe human immune system functions to provide continuous body-wide surveillance to detect and eliminate foreign agents such as bacteria and viruses as well as the body's own cells that undergo malignant transformation....
- 17From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedTo investigate the stability and functional role of long-residence water molecules in the Q61H variant of the signaling protein K-ras, we analyzed all available Ras crystal structures and conformers derived from a...
- 18From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedElucidation of new biomarkers and potential drug targets from high-throughput profiling data is a challenging task due to a limited number of available biological samples and questionable reproducibility of differential...
- 19From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedA striking feature of vascular plants is the regular arrangement of lateral organs on the stem, known as phyllotaxis. The most common phyllotactic patterns can be described using spirals, numbers from the Fibonacci...
- 20From: PLoS Computational Biology. (Vol. 8, Issue 2) Peer-ReviewedTumor cells do not develop in isolation, but co-evolve with stromal cells and tumor-associated immune cells in a tumor microenvironment mediated by an array of soluble factors, forming a complex intercellular signaling...