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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 8AndIssue Number: 12AndStart Page: e1003161AndDate: 2012 Revise Search
- 1From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedDNA amplification is a molecular process that increases the copy number of a chromosomal tract and often causes elevated expression of the amplified gene(s). Although gene amplification is frequently observed in cancer...
- 2From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedGenome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second ([FEV.sub.1]), and its ratio to forced vital capacity...
- 3From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedMutations in the BREVIPEDICELLUS (BP) gene of Arabidopsis thaliana condition a pleiotropic phenotype featuring defects in internode elongation, the homeotic conversion of internode to node tissue, and downward pointing...
- 4From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedTransposable elements (TEs) have the potential to act as controlling elements to influence the expression of genes and are often subject to heterochromatic silencing. The current paradigm suggests that heterochromatic...
- 5From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedChanges in genomic DNA methylation patterns are generally assumed to play an important role in the etiology of human cancers. The Dnmt3a enzyme is required for the establishment of normal methylation patterns, and...
- 6From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedAggregation is a social behavior that varies between and within species, providing a model to study the genetic basis of behavioral diversity. In the nematode Caenorhabditis elegans, aggregation is regulated by...
- 7From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedThe engulfment of apoptotic cells is required for normal metazoan development and tissue remodeling. In Caenorhabditis elegans, two parallel and partially redundant conserved pathways act in cell-corpse engulfment. One...
- 8From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedGenome duplication, which results in polyploidy, is disruptive to fundamental biological processes. Genome duplications occur spontaneously in a range of taxa and problems such as sterility, aneuploidy, and gene...
- 9From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedIn many human fungal pathogens, genes required for disease remain largely unannotated, limiting the impact of virulence gene discovery efforts. We tested the utility of a cross-species genetic interaction profiling...
- 10From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedNumerous genetic and epigenetic alterations render cancer cells selectively dependent on specific genes and regulatory pathways, and represent potential vulnerabilities that can be therapeutically exploited. Here we...
- 11From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedThe sensory systems of multicellular organisms are designed to provide information about the environment and thus elicit appropriate changes in physiology and behavior. In the nematode Caenorhabditis elegans, sensory...
- 12From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedDespite their classical role as transcriptional repressors, several histone deacetylases, including the baker's yeast Set3/Hos2 complex (Set3C), facilitate gene expression. In the dimorphic human pathogen Candida...
- 13From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedEpigenetic regulation of gene expression, including by Polycomb Group (PcG) proteins, may depend on heritable chromatin states, but how these states can be propagated through mitosis is unclear. Using immunofluorescence...
- 14From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedMalaria vectors in sub-Saharan Africa have proven themselves very difficult adversaries in the global struggle against malaria. Decades of anti-vector interventions have yielded mixed results--with successful reductions...
- 15From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedFragile X syndrome (FXS) is a form of inherited mental retardation in humans that results from expansion of a CGG repeat in the Fmr1 gene. Recent studies suggest a role of astrocytes in neuronal development. However,...
- 16From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedChromosomal inversions have been an enduring interest of population geneticists since their discovery in Drosophila melanogaster. Numerous lines of evidence suggest powerful selective pressures govern the distributions...
- 17From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedDuring echinoderm development, expression of nodal on the right side plays a crucial role in positioning of the rudiment on the left side, but the mechanisms that restrict nodal expression to the right side are not...
- 18From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedIn the fission yeast Schizosaccharomyces pombe, the transcriptional-regulatory network that governs flocculation remains poorly understood. Here, we systematically screened an array of transcription factor deletion and...
- 19From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedExperimental autoimmune orchitis (EAO), the principal model of non-infectious testicular inflammatory disease, can be induced in susceptible mouse strains by immunization with autologous testicular homogenate and...
- 20From: PLoS Genetics. (Vol. 8, Issue 12) Peer-ReviewedDrosophila telomere maintenance depends on the transposition of the specialized retrotransposons HeT-A, TART, and TAHRE. Controlling the activation and silencing of these elements is crucial for a precise telomere...